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Randomized Trial of Dexamethasone Injection for Postoperative Pain After Third Molar Surgery

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Summary

The NIH ClinicalTrials.gov registry published a new study entry (NCT07538375) for a randomized clinical trial evaluating dexamethasone injection effectiveness for reducing postoperative pain following surgical removal of impacted mandibular third molars. The trial enrolls patients at 28 Military Dental Centre, Lahore, comparing standard local anesthesia alone against local anesthesia plus dexamethasone injection, with pain assessed via Visual Analogue Scale at 24, 48, and 72 hours post-surgery.

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What changed

This entry adds a new clinical trial registration to the NIH ClinicalTrials.gov database. The trial, designated NCT07538375, is a randomized controlled study at a military dental centre in Lahore assessing whether postoperative dexamethasone injection reduces pain after third molar surgery compared to standard local anesthesia alone. No regulatory obligations or compliance requirements are created by this registry entry.

Affected parties include clinical investigators conducting oral surgery research and healthcare providers interested in postoperative pain management protocols. The trial's findings, upon completion, may inform future clinical practice regarding corticosteroid use in dental surgery but impose no immediate compliance obligations on external parties.

Archived snapshot

Apr 21, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← ClinicalTrials.gov Studies

Effectiveness of Dexamethasone Injection for Reducing Pain After Third Molar Surgery

N/A NCT07538375 Kind: NA Apr 20, 2026

Abstract

This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Patients are divided into two groups: one receiving standard local anesthesia, and the other receiving an additional dexamethasone injection postoperatively. Pain levels are assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours after surgery. The study is conducted at 28 Military Dental Centre, Lahore.

Conditions: Impacted Mandibular Third Molar, Postoperative Pain

Interventions: Dexamethasone

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Classification

Agency
NIH
Instrument
Notice
Branch
Executive
Legal weight
Non-binding
Stage
Final
Change scope
Minor

Who this affects

Applies to
Clinical investigators Healthcare providers
Industry sector
6211 Healthcare Providers
Activity scope
Clinical trial registration Postoperative pain management
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Topics
Pharmaceuticals

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