US20260109748A1 - Plasmacytoid Dendritic Cell Binding Agents
Summary
The USPTO published application US20260109748A1, filed August 13, 2025, disclosing chimeric proteins and protein complexes that bind plasmacytoid dendritic cells (pDC), including Clec4C targets. Invented by Nikolai KLEY, Jan TAVERNIER, Anje CAUWELS, Lennart ZABEAU, and Erik DEPLA, the disclosed agents and pharmaceutical compositions are proposed for diagnostic and therapeutic applications, including treatment of autoimmune diseases. The application has been published for examination but has not yet been granted.
“The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents.”
About this source
USPTO classification C07K covers peptides: short amino-acid chains that form the backbone of antibodies, hormones, vaccines, and increasingly a wider class of therapeutic modalities. Every newly published application in C07K lands in this feed, around 175 a month. Applications publish 18 months after filing, so this feed reveals what antibody engineering groups, vaccine developers, and plant biotech researchers were working on in the prior year and a half. Watch this if you compete in biologics, file freedom-to-operate analyses on antibody drug candidates, scout acquisition targets in vaccine platforms, or track protein-based agricultural biotech filings.
What changed
The USPTO published patent application US20260109748A1 covering agents, chimeric proteins, and chimeric protein complexes that bind plasmacytoid dendritic cells (pDC), specifically targeting Clec4C. The application discloses pharmaceutical compositions containing these binding agents and their use in diagnostic and therapeutic methods, including treatment of autoimmune diseases.
Pharmaceutical and biotechnology companies developing immunotherapy platforms, autoimmune disease treatments, or dendritic cell-based diagnostics should monitor this application's prosecution. While a published application does not create enforceable patent rights, it establishes prior art that could affect freedom-to-operate analyses for competing therapeutic or diagnostic products targeting pDCs.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MODULATION OF DENDRITIC CELL LINEAGES
Application US20260109748A1 Kind: A1 Apr 23, 2026
Inventors
Nikolai KLEY, Jan TAVERNIER, Anje CAUWELS, Lennart ZABEAU, Erik DEPLA
Abstract
The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents. The present Invention further relates to pharmaceutical compositions comprising the pDC, e.g. Clec4C, binding agents, chimeric proteins, or chimeric protein complexes and their use in the treatment of various diseases, including autoimmune diseases.
CPC Classifications
C07K 14/56 A61P 35/00 C07K 14/565 C07K 16/2815 C07K 16/2818 C07K 16/2827 C07K 16/2851 C07K 16/2896 A61K 38/00 A61K 2039/505 C07K 2317/22 C07K 2317/31 C07K 2317/569 C07K 2317/71 C07K 2317/73 C07K 2317/76 C07K 2319/30 C07K 2319/33 C07K 2319/74
Filing Date
2025-08-13
Application No.
19298570
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