Dana-Farber HDAC Degrader Patent, Apr 15
Summary
The EPO published patent application EP4333842A1 for Class IIA Histone Deacetylase (HDAC) Degrader Ligands filed by Dana-Farber Cancer Institute, Inc., with inventors Fischer, Eric S., Xiong, Yuan, and Donovan, Katherine. The application covers compounds classified under A61K 47/55, C07D 413/14, C07D 401/04, and C07D 401/14, with designated states spanning all 31 EPC contracting states including DE, FR, GB, IT, NL, ES, PL, and SE. The therapeutic applications indicated include oncology (A61P 35/04) and neurological disorders (A61P 25/28), with compounds based on five-membered heterocyclic structures (A61K 31/4245).
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GovPing monitors EPO Patent Bulletin - Organic Chemistry (C07D) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 51 changes logged to date.
What changed
The EPO published patent application EP4333842A1 establishing a priority date for Class IIA Histone Deacetylase (HDAC) Degrader Ligands and associated methods of use. The application designates all 31 EPC contracting states and covers specific therapeutic applications in oncology and neurological disorders.
Pharmaceutical and biotech companies developing targeted protein degradation therapies, particularly HDAC-based oncology candidates, should monitor this application's prosecution. The designated states include major European pharmaceutical markets (DE, FR, GB, IT, ES), and the therapeutic classifications suggest potential competition in cancer and neurodegenerative disease treatment pipelines.
Archived snapshot
Apr 25, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
CLASS IIA HISTONE DEACETYLASE (HDAC) DEGRADER LIGANDS AND METHODS OF USE THEREOF
Publication EP4333842A1 Kind: A1 Apr 15, 2026
Applicants
Dana-Farber Cancer Institute, Inc.
Inventors
FISCHER, Eric S., XIONG, Yuan, DONOVAN, Katherine
IPC Classifications
A61K 47/55 20170101AFI20260311BHEP A61P 35/04 20060101ALI20260311BHEP A61P 25/28 20060101ALI20260311BHEP A61K 31/4245 20060101ALI20260311BHEP C07D 413/14 20060101ALI20260311BHEP C07D 401/04 20060101ALI20260311BHEP C07D 401/14 20060101ALI20260311BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
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