Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
Summary
ClinicalTrials.gov registered observational study NCT07544277 on April 22, 2026, evaluating Photon Counting Detector (PCD)-CT technology combined with Fractional Flow Reserve derived from CT (FFR-CT) and spectral CT perfusion (CTP) for non-invasive detection of significant coronary artery disease (CAD). The study aims to address limitations of energy-integrating detector CT, where FFR-CT shows suboptimal performance and CTP involves high radiation exposure. Conditions under study include FFR-CT, CT angiography, CT perfusion, and coronary arterial disease.
“Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks.”
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What changed
ClinicalTrials.gov registered a new observational study (NCT07544277) titled "Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT." The study focuses on evaluating Photon Counting Detector (PCD)-CT technology, which may overcome limitations of conventional energy-integrating detector CT in assessing coronary artery disease hemodynamics. The study covers conditions including FFR-CT, CT angiography, CT perfusion, and coronary arterial disease, with no stated compliance deadline or penalty information.
Healthcare providers and clinical investigators involved in cardiac imaging research may benefit from awareness of this trial's methodology, as its findings could inform future non-invasive assessment approaches for myocardial ischemia. Medical device manufacturers producing advanced CT systems, particularly photon-counting detector technology, may find this trial relevant to product development and evidence-generation pathways.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
Observational NCT07544277 Kind: OBSERVATIONAL Apr 22, 2026
Abstract
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited specificity for a tendency to overestimate stenoses and for the lack of information about their hemodynamic impact. Fractional Flow Reserve derived from CT (FFR-CT) and stress CT perfusion (CTP) have been recently proposed to complement CCTA in the non-invasive assessment of myocardial ischemia, increasing the specificity and avoiding unnecessary catheterization. However, on energy-integrating (EID)-CT, FFR-CT has suboptimal performance, while CTP is affected by high radiation exposure. Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks. Aim of the study is to assess the performance of PCD-CT in the identification of significant CAD combining CCTA with FFR-CT and spectral CTP.
Conditions: FFR-CT, CT Angiography, CT Perfusion, Coronary Arterial Disease (CAD)
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