Chimeric Klebicins - Bactoclear Holdings
Summary
The USPTO granted US Patent 12,606,598B2 to Bactoclear Holdings PTE, Ltd. covering chimeric klebicins — engineered antimicrobial proteins combining translocation, receptor-binding, and bactericidal domains from different klebicin sources. The patent includes 15 claims and covers compositions, kits, and methods of use designed to improve target cell range and bactericidal activity against bacterial pathogens.
What changed
The USPTO issued Patent 12,606,598B2 for chimeric klebicins to Bactoclear Holdings PTE, Ltd., covering a class of engineered antimicrobial proteins that combine functional domains from multiple klebicin sources to broaden target cell range and enhance bactericidal activity. The patent protects the compositions, kits, and methods of use disclosed.
Pharmaceutical and biotechnology companies developing antimicrobial or protein-based therapeutics should review this grant to assess freedom-to-operate in the klebicin space. Competitors pursuing similar domain-shuffling approaches to bactericidal proteins may need to evaluate potential infringement exposure or explore licensing arrangements with the assignee.
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Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Chimeric klebicins
Grant US12606598B2 Kind: B2 Apr 21, 2026
Assignee
Bactoclear Holdings PTE, Ltd.
Inventors
Anisha Ambady, Chemira Biddappa Appaiah, Vivek Daniel Paul, R. Sanjeev Saravanan, Keerthana Anbalagan
Abstract
The present invention provides chimeric klebicins by combining translocation, receptor-binding, and bactericidal domains originated from different klebicins to achieve improved target cell range and bactericidal activity. Also provided are related compositions, kits, and methods of use of these chimeric klebicins.
CPC Classifications
C07K 14/26 C07K 2319/00 A61K 9/0019 A61K 9/0073 A61K 38/164 A61P 31/04
Filing Date
2022-07-08
Application No.
17811492
Claims
15
Mentioned entities
Parties
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