USPTO Patent Applications - Biotech (C12N)

Delayed Harvest Methods for Short Stature Corn Plants

The USPTO has published a patent application (US20260083046A1) detailing methods for delayed harvesting of short stature corn plants. The application, filed on October 23, 2025, aims to provide growers with a flexible harvesting window to optimize drying or seed access without increasing yield loss risk.

Method Predicts Prime Editing Efficiency in Different Cell Types

The USPTO has published a patent application (US20260088126A1) detailing a method and device for predicting prime editing efficiency in various cell types and prime editor types. The application, filed by Yonsei University, focuses on training predictive models for both on-target and off-target prime editing efficiency.

Patent Application for mRNA Design

The USPTO has published patent application US20260088125A1 concerning methods for designing synthetic RNA molecules, specifically for mRNA design. The application details a process for obtaining coding sequences and selecting regions for synthetic RNA molecule production.

Patent Application for Cell Manipulation Device and Method

The USPTO has published a new patent application (US20260086001A1) for a cell manipulation device and method. The application, filed on December 1, 2025, describes a technique for culturing cells by attaching them to an air bubble formed in a liquid flow path. This is a routine publication of a patent application.

Cardio-Tox TEEM Model for Cardiotoxicity and Arrhythmia Risk Assessment

The USPTO has published a patent application detailing the Cardio-Tox Tissue Engineered Model (TEEM). This in vitro model uses 3D human heart microtissues to assess cardiotoxicity and arrhythmia risk from test compounds, aiming to establish safe human exposure levels for environmental and pharmaceutical substances.

Viscoelastic Hydrogel Regulates Organoid Patterning and Vascularization

The USPTO has published a new patent application, US20260086082A1, detailing a viscoelastic hydrogel for regulating organoid patterning and vascularization. The application, filed by inventors Changchun Zeng, Yan Li, and Xingchi Chen, focuses on a spinal cord model.

Viscoelastic Hydrogel Regulates Organoid Patterning and Vascularization

The USPTO has published a new patent application, US20260086081A1, detailing a viscoelastic hydrogel for regulating organoid patterning and vascularization. The application, filed on April 10, 2025, describes spinal cord models using methacrylated hyaluronic acid and dopamine-modified hyaluronic acid.

Ovarian and Uterine Organoid Production and Pharmaceutical Screening

The USPTO has published a patent application detailing methods for producing ovarian and uterine organoids from stem cells. These organoids are intended for use in screening pharmaceutical interventions for diseases and for applications in hormone replacement therapy and assisted reproduction technologies.

Enzyme-containing article with water barrier properties

The USPTO has published a new patent application, US20260085163A1, detailing an enzyme-containing biodegradable single-layer article with water barrier properties. The application was filed by Vincent Legrand and includes various CPC classifications related to polymers and enzymes.

Patent Application: Method of Differentiating Pluripotent Stem Cells to Hematopoietic Cells

The USPTO has published a patent application (US20260085288A1) detailing a method for differentiating pluripotent stem cells into hematopoietic precursor and stem cells. The application, filed by Boris Greber and Daniel Terheyden-Keighley, outlines a process using specific induction cocktails for generating immune cells like NK cells.

Therapeutic Macrophages Patent Application

The USPTO has published a patent application (US20260085287A1) filed by Resolution Therapeutics Limited for therapeutic macrophages genetically engineered to overexpress Interleukin-10 (IL-10) or IL-10 in combination with Matrix Metallopeptidase 9 (MMP9). This application relates to potential treatments for inflammatory conditions.

Anti-tumor immune response enhancer patent application

The USPTO has published a new patent application, US20260085286A1, detailing an 'Anti-tumor immune response enhancer'. The application, filed by Kenichiro Hasumi, describes a composition comprising phospholipids to enhance anti-tumor activity and induce cytokine production.

Methods for Producing Retinal Pigment Epithelium Cells

The USPTO has published a new patent application detailing methods for producing retinal pigment epithelium (RPE) cells. The application describes specific culturing and replating techniques using laminin substrates to expand and mature RPE cells for potential therapeutic uses.

Stem cell-derived gastruloid model and construction method

The USPTO has published a patent application detailing a stem cell-derived gastruloid model and its construction method. This model simulates early embryonic development and can be used for drug screening and safety testing, particularly for early pregnancy applications.

Patent Application for On-Board Lysis Capsule in Fluidic Cartridge

The USPTO has published a patent application (US20260085275A1) for an on-board lysis capsule designed for fluidic cartridges. The capsule contains beads and magnetic elements for cell lysis and may include an internal control for assay validation. The application was filed by Gen-Probe Incorporated.

Patent Application: Culture Medium Production Using Microbial Co-Hydrolysis

The USPTO has published a patent application (US20260085281A1) detailing a method for producing culture medium through microbial co-hydrolysis of plant proteins. The application, filed on April 10, 2025, aims to improve soil and cultivation effects using waste seasoning.

Patent Application for Modified Microorganisms Consuming Xylose

The USPTO has published a patent application (US20260085280A1) for methods of modifying microorganisms to increase xylose consumption. The application, filed by MARA RENEWABLES CORPORATION, details processes for enhancing microbial growth on hemicellulosic carbohydrates.

Corynebacterium Mutant Strain for Enhanced L-Arginine or L-Citrulline Productivity

The USPTO has published a patent application by Daesang Corporation for a Corynebacterium mutant strain designed for enhanced L-arginine or L-citrulline productivity. The application details a method for producing these amino acids using the modified strain, which exhibits increased activity in the L-arginine biosynthesis pathway.

Genetically Modified Clostridium Acetobutylicum for Lignocellulosic Biomass

The USPTO has published a patent application (US20260085278A1) detailing genetically modified Clostridium acetobutylicum strains designed for efficient growth on lignocellulosic biomass. The application, filed by Institut National des Sciences Appliquees de Toulouse, describes overexpressing specific operons to enhance biomass conversion for producing bulk chemicals like ethanol and butanol.

Patent Application for Microorganism and Ergothioneine Production

The USPTO has published a patent application (US20260085277A1) from Kureha Corporation detailing a novel microorganism and a method for producing ergothioneine. The application includes specific microorganism accessions and CPC classifications related to biotechnology and chemical synthesis.

Patent Application for Mycelium Substrate Preparation

The USPTO has published a new patent application (US20260085276A1) detailing means and methods for preparing a mycelium-colonized substrate. The application, filed on September 25, 2023, describes a method involving incubating a substrate with synthetic granulometry regulators and a solid-state mycelium bioreactor.

Patent Application for Fermentation Process Standardization

The USPTO has published a patent application (US20260085274A1) from Precision Fermentation, Inc. The application details methods and systems for standardizing fermentation processes, including constructing baseline databases and initiating new process instances. This is a new patent application filing.

Electroporation Apparatus and Methods Patent Application

The USPTO has published a patent application (US20260085268A1) filed by MaxCyte, Inc. on September 6, 2023. The application describes an apparatus and methods for electroporation of cells, including safety features like an emergency stop button. This is a new patent application and does not impose new regulatory requirements.

USPTO patent application for bioprocess on cell cultures

The USPTO has published a patent application (US20260085266A1) detailing a method for performing a bioprocess on liquid immune or naive cell cultures. The application, filed on December 13, 2022, describes an integrated bioprocessing system with preconfigurable cartridges for cell therapy.

Chimeric Transposases and Fusion Proteins Patent Application

The USPTO has published a new patent application (US20260085332A1) detailing chimeric transposases and fusion proteins. The application, filed on October 3, 2025, by inventors Joseph S. Lucas, Blair B. Madison, and Olga Batalov, covers polynucleotides, vectors, and methods for modifying cells using these proteins.

Alpha-amylase variants and polynucleotides patent application

The USPTO has published a new patent application, US20260085261A1, from Novozymes A/S concerning alpha-amylase variants and related polynucleotides. The application details specific molecular constructs and their potential uses.

US Patent Application for PDCD1 Knockout RNA Molecule

The USPTO has published a new patent application (US20260085331A1) for an RNA molecule designed for biallelic knockout of PDCD1. The application, filed on September 18, 2023, details compositions comprising RNA molecules with specific guide sequences and their methods of use.

Breast Cancer Detection Kit, Device, and Method Patent Application

The USPTO has published a patent application (US20260085359A1) from TORAY INDUSTRIES, INC. for a breast cancer detection kit, device, and method. The application describes a kit or device comprising nucleic acids that specifically bind to a miRNA in a subject's sample, and a method for detecting breast cancer by measuring the miRNA in vitro.

Methods for rapid multiplex HLA genotyping and transcript quantitation

The USPTO has published a new patent application detailing methods for rapid multiplex HLA genotyping and transcript quantitation using nanopore technology. The application, assigned to The University of North Carolina at Chapel Hill, outlines techniques for determining HLA status and genotyping donor cells for transplantation.

Viral Protein Expression Patent Application

The USPTO has published a new patent application, US20260085328A1, filed on September 8, 2023. The application describes methods and systems for producing adeno-associated virus (AAV) particles using insect cells.

Patent Application: Disruption of GROOT Gene Function Increases Plant Biomass

The USPTO has published a patent application (US20260085325A1) from the Salk Institute for Biological Studies detailing methods to enhance plant biomass and seed size by reducing the expression of GROOT1, GROOT2, and GROOT3 genes. The application describes compositions and transformed plants generated using these methods.

Method for Detecting Polynucleotide Analyte Using CRISPR/Cas Effector

The USPTO has published a new patent application detailing a method for detecting polynucleotide analytes using CRISPR/Cas effector technology. The application, filed by inventors from USPTO, describes a method involving a cleaving agent with flap endonuclease activity and a type V CRISPR/Cas effector protein, specifically a Cast2 protein.

Patent Application for Pseudomonas Recombinant Protein Expression

The USPTO has published a new patent application, US20260085338A1, detailing a Pseudomonas sp. strain for recombinant protein expression. The application was filed on September 6, 2023, and relates to novel expression systems for biotechnological applications.

Patent Application for Plant Regulatory Elements and Uses

The USPTO has published a patent application (US20260085324A1) detailing novel synthetic small nuclear RNA (snRNA) promoters for CRISPR-mediated gene modifications in plants. The application, filed on October 3, 2025, includes methods and compositions for developing plants with modified genomes using these promoters.

Patent Application for Metabolism Disease Therapeutic Agents

The USPTO has published a new patent application (US20260085322A1) for therapeutic agents targeting metabolism-associated diseases, such as MAFLD. The application was filed on September 6, 2023, by inventors from the USPTO.

Method for Producing Oil Composition via Biomass Fermentation

The USPTO has published a patent application detailing a method for producing an oil composition through the fermentation of biomass using specific yeast strains. The application outlines a preparation stage, a fermentation stage with controlled temperature and pH, and an oil procurement stage involving mechanical cell lysis.

Engineered Ketoreductases for Chiral Alcohol Preparation

The USPTO has published a patent application (US20260085334A1) for engineered ketoreductase polypeptides developed by Enzymaster (Ningbo) Bio-Engineering Co., Ltd. The patent describes enzymes capable of preparing chiral alcohols with high catalytic activity, stereoselectivity, thermal stability, and solvent tolerance.

Patent Application: Iron Metabolism Targets for Obesity Treatment

The USPTO has published a new patent application (US20260085321A1) detailing methods for treating obesity by inhibiting specific iron metabolism genes. The application, filed on September 24, 2025, by inventor Richard Possemato, proposes inducing weight loss through increased lipid catabolism.

GalNAc Monomer for Liver-Targeted Nucleic Acid Drug Delivery

The USPTO has published a patent application detailing a GalNAc monomer for liver-targeted delivery of small nucleic acid drugs. The application, filed by inventors Zeao Huang et al., describes a compound that enhances drug efficacy through efficient liver targeting.

USPTO Patent Application: Neuron Generation from Pluripotent Stem Cells

The USPTO has published a patent application (US20260079153A1) detailing methods for generating mature neurons from pluripotent stem cells. The disclosed methods involve overexpressing specific splicing factors to facilitate the study of neurodegenerative diseases and the accelerated derivation of mature neurons.

USPTO Patent Application: 3D Immunomechanical Organoid Model

The USPTO has published a patent application (US20260079151A1) for a 3D immunomechanical organoid model developed by the University of Notre Dame. This model is designed for observing myeloid cell interactions and for applications in drug screening and microgravity experiments.

USPTO Patent Application for Magnetic Separation of Biological Populations

The USPTO has published a new patent application (US20260079086A1) detailing an apparatus, system, and method for high-yield magnetic separation of biological populations. The application describes a system involving a cell engineering cassette, a fluidic pathway with entrapment features, and a translatable magnet array for separating subpopulations.

USPTO Patent Application: VOCs for Cellular Communication

The USPTO has published patent application US20260079169A1, detailing a method for evaluating cancer behavior using volatile organic compounds (VOCs) detected in a mutual headspace between cancer cells and control samples. The application, filed on November 24, 2025, by inventors from institutions including Technion-Israel Institute of Technology, outlines a novel diagnostic approach.