Cardiac MRI Perfusion Analysis for Myocardial Health
ClinicalTrials.gov Studies
Summary
ClinicalTrials.gov registered study NCT07548879 describing a research protocol using cardiac MRI with contrast agents to develop fully quantitative myocardial perfusion analysis algorithms for assessing cardiac muscle health across patient populations including those with coronary artery disease and post-transplant vasculopathy.
“Fully quantitative perfusion analysis is highly needed for nearly all cardiac patients to better characterise the health and status of the myocardium.”
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What changed
This ClinicalTrials.gov registration describes an observational research protocol led by NIH-affiliated investigators studying cardiac MRI perfusion quantification methods using contrast-enhanced imaging to assess myocardial health.
Healthcare providers and clinical researchers involved in cardiac imaging should note this study focuses on developing and validating new perfusion algorithms to overcome limitations of existing methods like ISP, with the goal of enabling fully quantitative cardiac MRI analysis applicable across broad cardiac patient populations.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Quantitative Analysis of Cardiac Muscle Perfusion
N/A NCT07548879 Kind: NA Apr 23, 2026
Abstract
Full quantitative perfusion of the myocardial wall using MRI is a difficult method for several reasons. First the perfusion algorithm is mostly only relatively available, usually available algorithms /e.g. ISP/ shows not precise results according to our measurements, secondly based on signal physics and nature of MRI scans is not easy to get absolute numbers and specific new algorithms must be developed and tested. Such a tool is not only needed for some special cohort of patients, like 3-vessel disease, coronary artery disease or diffuse coronary artery involvement in coronary vasculopathy in patients after heart transplantation. Fully quantitative perfusion analysis is highly needed for nearly all cardiac patients to better characterise the health and status of the myocardium.
Conditions: Myocardial Ischemia
Interventions: Magnetic Resonance Imaging with Contrast
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