12-Week In-Phase Bilateral Exercise Programme Improves Corticospinal Plasticity in Progressive Multiple Sclerosis
Summary
Five individuals with Progressive Multiple Sclerosis completed a 12-week exercise programme of in-phase bilateral upper-limb movements three times per week, with brain activity measured via transcranial magnetic stimulation (TMS). The single-case experimental design with repeated baseline and intervention measurements assessed corticospinal excitability and functional outcomes including walking speed, balance, and cognition. Results are posted on ClinicalTrials.gov as a completed registry entry.
“In this study, five individuals with Progressive Multiple Sclerosis participated in a 12-week exercise program consisting of in-phase bilateral upper-limb movements performed three times per week.”
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What changed
NCT07548242 is a registered clinical trial entry on ClinicalTrials.gov describing a prospective single-site exploratory study. The study enrolled five participants with Progressive Multiple Sclerosis to evaluate whether a structured 12-week in-phase bilateral upper-limb exercise programme (three sessions per week) can produce measurable neurophysiological and functional changes, assessed via TMS active motor threshold measurements and clinical outcome measures.
The registry entry is informational and does not impose regulatory obligations on any party. Healthcare researchers conducting similar neurological rehabilitation studies should be aware that the study was prospectively registered on ClinicalTrials.gov; results posting is a transparency requirement rather than a compliance obligation. Peer institutions or sponsors reviewing this entry for protocol design purposes may note the TMS measurement methodology and single-case experimental design as potential reference points.
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Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
The Effects of a 12-week In-phase Bilateral Exercise Programme on the Corticospinal Plasticity in People With Progressive Multiple Sclerosis
N/A NCT07548242 Kind: NA Apr 23, 2026
Abstract
This study investigates whether a structured exercise program using coordinated movements of both arms can improve brain and motor function in people with Progressive Multiple Sclerosis (MS). Progressive MS is associated with gradual worsening of neurological function, including difficulties with movement, strength, balance, and cognition. Because current medications have limited effects on disease progression, rehabilitation strategies that promote brain plasticity and functional recovery are increasingly important.
In this study, five individuals with Progressive Multiple Sclerosis participated in a 12-week exercise program consisting of in-phase bilateral upper-limb movements performed three times per week. Brain activity related to movement was measured using transcranial magnetic stimulation (TMS), which assessed corticospinal excitability through active motor threshold measurements. Additional clinical tests evaluated walking speed, balance, hand dexterity, muscle strength, cognitive processing speed, fatigue, and quality of life. The study used a single-case experimental design with repeated measurements during baseline and intervention phases to determine whether the exercise program produced measurable neurophysiological and functional changes.
Conditions: Progressive Multiple Sclerosis (PMS)
Interventions: In-Phase Bilateral Upper Limb Exercise Program
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