PEPFAR Transition-Year Baseline Data Release
Summary
The State Department released PEPFAR transition-year baseline data for Q3 2025 (July–September), covering the initial absorption of USAID PEPFAR programming into the Department. Programs provided antiretroviral treatment to 20.6 million people living with HIV across more than 50 countries. The data also shows declining pediatric HIV treatment numbers (508,703 in 2025, down from 643,627 in 2022) and declining positive HIV tests (1,136,488 in 2025, down from 1,693,349 in 2022), reflecting progress in preventing mother-to-child transmission.
What changed
This fact sheet releases official U.S. Government statistics on PEPFAR program outcomes for the July–September 2025 quarter, marking the transition of USAID PEPFAR programming to the Department of State's Bureau of Global Health Security and Diplomacy. Key metrics include 20.6 million people on antiretroviral treatment, 103,000 pregnant and breastfeeding women initiated on pre-exposure prophylaxis, and declining trends in pediatric HIV cases and positive test rates.
Affected parties include HIV/AIDS implementing partners, international health organizations, and donor agencies tracking U.S. Government health assistance. The data provides a baseline for measuring the impact of the transition and the America First Global Health Strategy going forward, but does not itself impose reporting or compliance obligations on private-sector entities.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Home Office of the Spokesperson Press Releases PEPFAR Data Release
PEPFAR Data Release
Fact Sheet
April 20, 2026
The report covers the period of July 1, 2025 – September 30, 2025, representing a transition-year baseline, including the absorption of USAID PEPFAR programming to the Department of State, and does not reflect the historic investments made through the America First Global Health Strategy. Below are the facts:
Anti-Retroviral Treatment
U.S. Government-supported programs provided anti-retroviral (ARV) treatment for 20.6 million people living with HIV in more than 50 countries, stable from FY 2024 Q4.
Pre-Exposure Prophylaxis for Pregnant and Breastfeeding WomenPEPFAR initiated 103,000 pregnant and breastfeeding women to start pre-exposure prophylaxis to protect them and their babies from HIV—more than doubling the 43,000 pregnant and breastfeeding women on pre-exposure prophylaxis just one year ago.
Declining Pediatric HIV Treatment Numbers Reflect Prevention SuccessThe number of children on HIV treatment declined from 643,627 in 2022 to 508,703 in 2025—representing year-over-year declines of 7 percent, 7 percent , and 9 percent respectively—reflecting tremendous progress in reducing mother-to-child transmission consistent with historical trends.
These declines are expected to continue, particularly with U.S. Government funding of Lenacapavir, which can further prevent mother-to-child transmission.
Declining HIV Positive Tests Demonstrate Epidemic ProgressPositive HIV tests declined from 1,693,349 in 2022 to 1,136,488 in 2025 – representing year-over-year declines of 14 percent, 12 percent, and 11 percent respectively – reflecting progress in combating the HIV epidemic consistent with historical trends.
This data does not reflect the impact of bilateral MOUs or the broader strategies being implemented under the America First Global Health Strategy.
Tags
Bureau of Global Health Security and Diplomacy Disease Prevention, Detection, and Response Health HIV/AIDS Office of the Spokesperson
Related changes
Get daily alerts for State Dept Press Releases
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from DOS.
The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when State Dept Press Releases publishes new changes.
Subscribed!
Optional. Filters your digest to exactly the updates that matter to you.