NSF EBBS Grant: Engineering Biological and Biomedical Systems Research
Summary
The National Science Foundation (NSF) Engineering Directorate has posted a funding opportunity for the Engineering Biological and Biomedical Systems (EBBS) program. The program supports fundamental research combining mechanistic insights with experimental and computational techniques to develop platforms, devices, organisms, tissues, and processes that advance understanding and control of biological functions. Proposals are accepted on a rolling basis; no specific award amounts or deadlines are stated. The program excludes proposals focused on drug design, drug delivery, animal model development, clinical trials, or commercialization.
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What changed
The EBBS program expands what is possible in biomanufacturing and health research by supporting studies of mechanisms that drive the behavior of microbial populations, cells, therapeutic cells, and tissues. Research includes discovering engineering principles to capture biological system responses, creating novel biosensing platforms, and developing optical imaging and modulation strategies.
Researchers seeking NSF funding for biological or biomedical engineering work should note that proposals must enable improved biological processes, create novel biomedical technologies, or achieve new understanding of physiological or pathological processes. The program explicitly excludes proposals with a main goal of drug design, drug delivery, or animal model development. Clinical trials are not supported. Projects focused on commercialization are directed to NSF's Directorate for Technology, Innovation, and Partnerships (TIP).
Archived snapshot
Apr 25, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Engineering Biological and Biomedical Systems (EBBS)
Agency: U.S. National Science Foundation
Assistance Listings: 47.041 -- Engineering
Last Updated: April 25, 2026 View version history on Grants.gov
Description
The Engineering Biological and Biomedical Systems (EBBS) program expand s our understanding of biological and physiological systems, and it helps improve human health. For U.S. leadership in biotechnology, the engineering of biology is required at every scale. E ngineering is needed for sensing biomarkers to making proteins to restoring function s of the body. In EBBS, fundamental mechanistic insight s are combine d with experimental and computational techniques. This approach help s develop platforms, devices, organisms, tissues, and processes that bring new understanding and control of biological function s.
... EBBS supports studies of mechanisms that driv e the behavior of microbial populations and cells, and of therapeutic cells and tissues. This includes discovering the underlying engineering principles that are needed to captur e the responses of biological systems and bioreactors. It also includes the creation of novel bio sensing platforms and new optical imaging and modulation strategies. Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight into tissue changes or injury, and to systems that imitate or restore the function s of tissues or organs are encouraged.
P rojects that advanc e rehabilitation engineering through new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by the needs of persons with disabilities is encouraged.
The EBBS program expand s what is possible in biomanufacturing; research may advance biotechnology and /or health. EBBS research must enabl e improved biological processes, create novel biomedical technologies, or achieve new understanding of physiological or pathological processes.
EBBS does not support proposals with a main goal of drug design, drug delivery, or t he development of animal models of disease. Using existing models for experimental testing and validation is acceptable. Projects that focus on testing and validating therapies are not supported. Clinical trials are not supported. L imited studies involving human volunteers may be supported if appropriate to the project objectives. Projects focused on commercialization are more appropriate for the NSF Directorate for Technology, Innovation, and Partnerships (TIP).
Partnerships: To speed discovery and innovation, NSF partners with federal agencies, industry, international groups, and others. Current opportunities are at NSF ENG Partnerships.
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Eligibility
Eligible applicants
Miscellaneous
- Unrestricted
Additional information
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Grantor contact information
Description
NSF grants.gov support
grantsgovsupport@nsf.gov
If you have any problems linking to this funding announcement, please contact the email address above.
Documents
No documents are currently available.
Link to additional information
NSF Program Desccription PD-26-369Y
Closing: --
Proposals accepted anytime
Application process
This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates. View on Grants.gov
Award
$--
Program Funding
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Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
PD-26-369Y
Cost sharing or matching requirement:
No Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
-- Category of Funding Activity:
Science technology and other research and development
Category Explanation:
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History
Version:
1
Posted date:
April 24, 2026
Archive date:
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