NIH Funding Opportunity: Clinical Coordinating Center for Multi-Site Trials

Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)

Agency: National Institutes of Health

Assistance Listings: 93.837 -- Cardiovascular Diseases Research

93.838 -- Lung Diseases Research

93.839 -- Blood Diseases and Resources Research

93.233 -- National Center on Sleep Disorders Research

93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

Last Updated: March 18, 2026 View version history on Grants.gov

Description

This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must... be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close gaps in health outcomes within the US population and increase health for all.Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application. Show full description

Eligibility

Eligible applicants

Education

• Public and state institutions of higher education
• Independent school districts
• Private institutions of higher education

Government

• State governments
• City or township governments
• Special district governments
• Public and Indian housing authorities
• County governments
• Federally recognized Native American tribal governments

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education without 501(c)(3)

Business

• Small businesses
• For-profit organizations other than small businesses

Miscellaneous

• Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Grantor contact information

Description

Division of Cardiovascular Sciences
NHLBIDCVSClinical@mail.nih.gov

Email

NHLBIDCVSClinical@mail.nih.gov

NHLBIDCVSClinical@mail.nih.gov

Documents

Download all
| File name | Description | Last updated |
| --- | --- | --- |
| PAR-27-012-Full-Announcement.html | PAR-27-012-Full-Announcement.html | Mar 18, 2026 12:46 PM UTC |

Link to additional information

--

Closing: November 2, 2028

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates. View on Grants.gov

Award

$--

Program Funding

--

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PAR-27-012

Cost sharing or matching requirement:

No Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

-- Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Posted date:

March 18, 2026

Archive date:

January 2, 2029