NIH SIREN Neurologic Clinical Trials Funding Opportunity Key Date Changes

NIH Guide Funding Opportunities

Published March 3rd, 2026

Detected March 5th, 2026

Summary

The National Institute of Neurological Disorders and Stroke (NINDS) has issued a notice updating key dates for the NIH SIREN Neurologic Clinical Trials funding opportunity (PAR-25-049). This notice adds new receipt dates for both new and renewal applications and extends the expiration date of the funding opportunity.

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What changed

The National Institute of Neurological Disorders and Stroke (NINDS) has issued a notice (NOT-NS-26-027) to amend the key dates for the NIH SIREN Neurologic Clinical Trials funding opportunity announcement (PAR-25-049). The amendment adds new receipt dates of June 6, 2026, for new applications and July 08, 2026, for renewal applications. Consequently, the expiration date for this funding opportunity has been extended to July 09, 2026.

Potential applicants for PAR-25-049 should note these updated deadlines when preparing and submitting their applications. The changes primarily affect the application submission timeline for the upcoming cycles. No other substantive changes to the funding opportunity requirements have been announced, but applicants should ensure they are referencing the most current key dates to avoid submission errors.

What to do next

Review updated key dates for PAR-25-049
Incorporate new receipt dates of June 6, 2026 (new) and July 08, 2026 (renewal) into application planning
Note the extended expiration date of July 09, 2026

Source document (simplified)

Notice of Change to Key Dates for PAR-25-049: NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required) Notice Number: NOT-NS-26-027

Key Dates

Release Date: March 3, 2026

Related Announcements

November 7, 2024 - NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required). See NOFO PAR-25-049 .

Issued by

National Institute of Neurological Disorders and
Stroke (NINDS)

Purpose

The purpose of this notice is to inform potential applicants of a change in the key dates for notice of funding opportunity (NOFO) PAR-25-049 , NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required). Specifically, an additional receipt date of June 6, 2026 has been added to this NOFO for new applications, and an additional receipt date of July 08, 2026 has been added to this NOFO for renewal applications. Accordingly, this NOFO now expires on July 9, 2026.

The following section of PAR-25-049 has been modified.

Part 1. Overview Information

Key Dates

Currently reads:

| Application Due Dates | | | Review and Award Cycles | | |
| --- | --- | | | | |
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
| February 07, 2025 | March 07, 2025 | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 06, 2025 | July 08, 2025 | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 07, 2025 | November 07, 2025 | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 06, 2026 | March 06, 2026 | Not Applicable | July 2026 | October 2026 | December 2026 |

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date: March 07, 2026

Modified to Read (key changes are adding additional line in table of receipt dates and updating expiration date **in bold italics)

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date: July 09, 2026