The Centers for Medicare & Medicaid Services published a Federal Register notice announcing a 60-day comment period under the Paperwork Reduction Act for two Clinical Laboratory Improvement Amendments (CLIA) information collections. The first item is a revision of CLIA Regulations (OMB Control No. 0938-0612) covering quality assessment, fees, histocompatibility, and personnel requirements, with approximately 49,626 respondents and 14,514,802 total annual hours. The second item is an extension of the collection on granting and withdrawal of deeming authority for private nonprofit accreditation organizations and CLIA exemption under state laboratory programs. Comments are due June 22, 2026.