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FDA Guidance: Inclusive Cancer Trial Eligibility Criteria

The FDA has issued new guidance recommending that sponsors and institutional review boards expand eligibility criteria for cancer clinical trials to include a wider range of patients, particularly concerning performance status. This aims to improve the diversity of clinical trial populations and ensure broader applicability of cancer treatments.

Financial Services Platform Test Approved by OSC, AMF, CIRO

Canada's OSC, AMF, and CIRO have approved Project Samara, an experimental research project evaluating a distributed ledger technology platform for bond transactions. The project involves major financial institutions and aims to assess the benefits of tokenized bond issuance and trading.

CIRO Annual Compliance Report 2026 for Dealers

The Canadian Investment Regulatory Organization (CIRO) has released its 2026 Annual Compliance Report. The report highlights emerging compliance challenges for dealers, including cybersecurity, crypto asset trading platforms, and the use of AI, and provides guidance on addressing these issues to enhance investor protection.

CIRO Guidance on Digital Asset Custody for Crypto-Asset Trading Platforms

The Canadian Investment Regulatory Organization (CIRO) has issued new guidance on digital asset custody for Crypto-Asset Trading Platforms (CTPs). The framework establishes clear expectations for Dealer Members operating CTPs, addressing technological, operational, and legal risks associated with digital assets. It enhances existing custody and segregation requirements to protect investors.

CIRO Guidance Expands Decision-Making Supports for OEO Dealers

The Canadian Investment Regulatory Organization (CIRO) has published new guidance allowing Order Execution Only (OEO) dealers to expand decision-making supports offered to clients. This aims to empower DIY investors with better educational resources and tools while maintaining investor protection.

FSA AI Discussion Paper Update for Financial Sector

The Financial Services Agency (FSA) of Japan has published Version 1.1 of its AI Discussion Paper, updating its previous 2025 version. This revision incorporates insights from public-private forums on AI utilization and risk management in the financial sector. The FSA is seeking comments on the paper to inform future policy development.

FSA Analytical Notes on Regional Banks and Talent

The Financial Services Agency (FSA) of Japan has published its "FSA Analytical Notes (2026.2)", focusing on the analysis of human resource support by regional banks and talent shortages in firms. An English version is expected to be released shortly.

MAS Issues Environmental Risk Transition Planning Guidelines

The Monetary Authority of Singapore (MAS) has issued new Guidelines on Environmental Risk Management - Transition Planning for banks, insurers, and asset managers. These guidelines set supervisory expectations for managing climate-related transition and physical risks, taking effect from September 2027.

FSB Report on Strengthening Global Bank Resolution Frameworks

The Financial Stability Board (FSB) released its 2025 Resolution Report, detailing progress in strengthening global resolution frameworks for banks, insurers, and financial market infrastructures. The report highlights achievements in 2025 and outlines future work to enhance crisis preparedness and operationalize resolution tools.

FSB Report on Repo Market Vulnerabilities

The Financial Stability Board (FSB) has released a report warning of vulnerabilities in government bond-backed repo markets. The report highlights potential contagion channels and emphasizes the need to preserve market functionality during stress periods, offering policy implications for regulators.