USPTO Patent Grant for Caged-Degron Molecular Feedback Circuits

ChangeBridge: Patent Grants - Peptides (C07K)

Published March 24th, 2026

Detected March 24th, 2026

Summary

The USPTO has granted patent US12583896B2 to The Regents of the University of California for caged-degron-based molecular feedback circuits. The patent covers methods of modulating signaling pathways in cells using these circuits, with a filing date of January 6, 2020.

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What changed

The United States Patent and Trademark Office (USPTO) has granted patent US12583896B2 for "Caged-degron-based molecular feedback circuits and methods of using the same." The patent, assigned to The Regents of the University of California, details molecular feedback circuits that utilize caged-degrons to control signaling pathways. It includes claims related to nucleic acids encoding these circuits, cells containing them, and methods for modulating cellular signaling pathways through genetic modification.

This patent grant is primarily relevant for entities involved in biotechnology research and development, particularly in the pharmaceutical and medical device sectors. While it does not impose direct compliance obligations, it signifies new intellectual property in the field of synthetic biology and cellular engineering. Companies operating in this space should be aware of this patent to ensure their research and development activities do not infringe upon the granted claims.

Source document (simplified)

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Caged-degron-based molecular feedback circuits and methods of using the same

Grant US12583896B2 Kind: B2 Mar 24, 2026

Assignee

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventors

David Baker, Scott Boyken, Hana El-Samad, Marc Lajoie, Robert Langan, Andrew Ng

Abstract

Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit.