Pyocyanin Demethylases Engineered for Bacteria
Summary
The USPTO published patent application US20260091089A1 for engineered pyocyanin demethylases with amino acid replacements at positions A53, 173, A87, T91, M99, A129, and K141 of PodA. The application covers compositions, methods, and systems for interfering with bacterial viability through pyocyanin demethylase activity, including synergistic combinations with antibiotics. Application 19312182 was filed August 27, 2025.
What changed
The USPTO published a patent application for engineered pyocyanin demethylases with seven specified amino acid replacements (positions A53, 173, A87, T91, M99, A129, K141) in the PodA enzyme sequence. The application (US20260091089A1, published April 2, 2026) covers compositions, methods, and systems for phenazine degradation to interfere with bacterial viability, including synergistic administration with antibiotics for enhanced inhibition of phenazine-producing bacteria. Inventors include Dianne K. Newman and colleagues from Caltech and Hebrew University.
Researchers and companies in antimicrobial, pharmaceutical, or biotechnology fields should monitor this patent application's prosecution status. Any entities developing antimicrobial technologies targeting pyocyanin or phenazine-producing bacteria should evaluate potential freedom-to-operate implications. No immediate compliance deadlines or regulatory requirements are associated with this patent publication.
What to do next
- Monitor USPTO patent prosecution status for US20260091089A1
- Evaluate potential licensing opportunities if developing related antimicrobial technologies
- Review patent claims for freedom-to-operate assessment in bacterial targeting research
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Pyocyanine Demethylases and related Phenazine Degrading Agents Compositions, Methods and Systems for Interfering with Viability of Bacteria
Application US20260091089A1 Kind: A1 Apr 02, 2026
Inventors
Dianne K. Newman, Chelsey M. VanDrisse, Rosalie Lipsh-Sokolik, Olga Khersonsky, Sarel J. Fleishman
Abstract
Provided herein are engineered pyocyanin demethylases having replacements in in positions A53, 173, A87, T91, M99, A129 and K141 of pyocyanin demethylase PodA of SEQ ID NO: 1 or a derivative thereof and related phenazine degrading agents, compositions, methods and systems, as well as a combined administration of one or more pyocyanin demethylases and antibiotics and/or antibiotics resulting in a synergic inhibition of viability of phenazine producing bacteria, and related phenazine degrading agents, compositions, methods and systems.
CPC Classifications
A61K 38/44 A61K 31/7036 A61P 31/04 C12N 9/0004
Filing Date
2025-08-27
Application No.
19312182
Named provisions
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