Method to Change Tumor Associated Macrophage Polarization Using Magnetosomes and Radiation
Summary
USPTO published patent application US20260097075A1 by Université Paris Cité for a method to change tumor-associated macrophage polarization by exposing macrophages to magnetosomes and radiation. The invention aims to shift macrophages from M0 or Mi polarization to Mj polarization for potential cancer immunotherapy applications.
What changed
USPTO published patent application US20260097075A1 for a method to control tumor-associated macrophage polarization using magnetosomes and radiation. The invention involves associating at least one tumor-associated macrophage with a nanoparticle (preferentially a magnetosome) and exposing the assembly to radiation, shifting macrophage polarization from M0 or Mi to Mj. CPC classifications include C12N 5/0645 and C12N 2506/115.
Pharmaceutical companies and medical device makers developing nanoparticle-based cancer immunotherapies should review this application for competitive IP implications. Researchers in the field should monitor the patent prosecution and assess freedom-to-operate for related therapeutic approaches targeting tumor microenvironment modulation.
What to do next
- Monitor for patent grant status
- Review claims for IP strategy
- Assess freedom-to-operate for nanoparticle macrophage targeting
Archived snapshot
Apr 9, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METHOD TO CHANGE THE POLARIZATION OF TUMOR ASSOCIATED MACROPHAGES BY EXPOSING THEM TO A SOURCE OF RADIATION IN THE PRESENCE OF MAGNETOSOMES
Application US20260097075A1 Kind: A1 Apr 09, 2026
Assignee
UNIVERSITE PARIS CITE
Inventors
Sonia BÉCHAREF, Edouard ALPHANDÉRY, Florence GAZEAU, Stéphane ROUX, Jean-Philippe HERBEUVAL, Léa JABBOUR, Nathalie LUCIANI, Amanda SILVA
Abstract
A method to control or change the polarization of at least one macrophage associated with a tumor or pathological site (TAM), from being predominantly a TAM with either no polarization (M0) or a polarization i (Mi) before at least one step of the method, to a predominant polarization j (Mj), by associating at least one TAM with a nanoparticle, preferentially a magnetosome, 10 and by exposing the assembly to a radiation, where Mi=Mi and Mj=M2 or Mi=M2 and Mj'M1.
CPC Classifications
A61K 35/15 C12N 5/0645 C12N 2506/115 C12N 2529/00
Filing Date
2025-10-03
Application No.
19349489
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