Methods of Making Trans Isomeric Forms of G Protein-Coupled Receptor Modulators

The USPTO published application US20260092049A1 covering methods of making trans isomeric forms of G protein-coupled receptor modulators. The application includes CPC classifications C07D 401/14, C07D 401/04, and C07D 495/04, indicating heterocyclic compound compositions relevant to pharmaceutical applications. The original filing date was September 5, 2025 (Application No. 19320950), with publication occurring on April 2, 2026. Eight inventors are named including Cyril Bucher, James P. Davidson, and others.

This patent publication does not impose regulatory obligations on third parties but establishes priority rights for the disclosed synthesis methods. Pharmaceutical companies developing GPCR-targeted therapeutics should review the claims to assess potential freedom-to-operate considerations. The publication is informational regarding the state of the art in trans isomeric GPCR modulator synthesis and does not require any compliance action.