T Cell Function Modulation Using CRISPR-Cas Epigenetic Systems

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COMPOSITIONS, SYSTEMS, AND METHODS FOR MODULATING T CELL FUNCTION

Application US20260097119A1 Kind: A1 Apr 09, 2026

Assignee

Tune Therapeutics, Inc.

Inventors

Akiko SEKI, Lucas James THOMPSON, Tyler S. KLANN, Alexandra CROFT, Nathaniel CHARTRAND, Nicole DENAMUR, Andrew HILL, Jason DEAN, Emi TOKUDA, Blythe SATHER

Abstract

Provided are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, that bind to or target a target site in a gene or regulatory element thereof in a T cell. In some aspects, the provided epigenetic modifying DNA-targeting systems modulate a T cell function, such as a T cell phenotype or activity. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in modulating T cells including in connection with methods of adoptive T cell therapy.

CPC Classifications

A61K 40/11 A61K 35/17 A61K 40/31 A61K 40/32 A61K 40/42 A61P 35/00 C12N 5/0636 C12N 5/10 C12N 9/222 C12N 15/1136 C12N 15/62 C12N 15/85 A61K 2239/48 C12N 2310/20 C12N 2510/00 C12N 2750/14143

Filing Date

2023-09-18

Application No.

19112945

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