Compositions and Methods for Controlling Production of Polypeptides in Cells

USPTO granted Patent US12600985B2 to the Board of Trustees of the Leland Stanford Junior University on April 14, 2026. The patent covers recombinant expression vectors with coding sequences flanked by recombinase recognition sites for modulating polypeptide production in target cells, methods for using these vectors, and devices for monitoring polypeptide expression. The patent application was filed on February 3, 2021, under Application No. 17796839.

Affected parties including researchers, biotech companies, pharmaceutical manufacturers, and healthcare institutions should monitor this patent for potential infringement implications. The patent grants Stanford exclusive rights to the claimed compositions and methods, which may affect work in recombinant DNA technology, synthetic biology, and protein production fields. Parties developing similar technologies should conduct freedom-to-operate analyses.