Rapamycin resistant cells
Summary
Seattle Children's Hospital has been granted US Patent 12595492B2 for rapamycin resistant cell compositions and methods. The patent covers proteins expressed in host cells to confer rapamycin resistance, with applications in modulating cell signaling and selective cell expansion. The patent contains 32 claims with six named inventors including Andrew M. Scharenberg and David J. Rawdings.
What changed
USPTO granted Patent No. 12595492B2 to Seattle Children's Hospital on April 7, 2026, covering compositions and methods for rendering host cells resistant to rapamycin, including proteins, cells, and methods for modulating cell signaling and selective cell expansion. The patent application was filed on April 10, 2024, under application number 18631675.
Affected parties including biotechnology firms, pharmaceutical companies, and research institutions should monitor this patent for freedom-to-operate considerations when developing cell-based therapies or research involving rapamycin-resistant cell lines. The patent may impact licensing negotiations and R&D strategies in the cell therapy and immunotherapy spaces.
What to do next
- Monitor for updates
- Review patent claims for potential infringement concerns
Archived snapshot
Apr 7, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Rapamycin resistant cells
Grant US12595492B2 Kind: B2 Apr 07, 2026
Assignee
Seattle Children's Hospital
Inventors
Andrew M. Scharenberg, David J. Rawlings, Karen Sommer, Samuel West, Yuchi Chiang Honaker, Ryo Takeuchi
Abstract
The present application relates to, inter alia, compositions including proteins for expression in host cells to render them resistant to rapamycin. The application further relates to methods of using the proteins, cells, and compositions disclosed therein for modulating cell signaling and for selective expansion of cells.
CPC Classifications
C12N 15/90
Filing Date
2024-04-10
Application No.
18631675
Claims
32
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