Autophagy Inducing Compounds and Uses Thereof

ChangeBridge: EPO Bulletin - Organic Chemistry (C07D)

Published March 25th, 2026

Detected April 2nd, 2026

Summary

The European Patent Office published patent application EP4433161A1, filed by Samsara Therapeutics Inc. and French research institutions INSERM, Université de Paris Cité, Sorbonne Université, and Assistance Publique - Hôpitaux de Paris. The patent covers autophagy-inducing compounds and their therapeutic uses for treating various diseases and conditions. The compounds are classified under multiple C07D heterocyclic ring structures.

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What changed

EPO published European patent application EP4433161A1 for novel autophagy-inducing compounds and their medical uses. The application covers compounds with heterocyclic structures (C07D 401/14, 403/04, 403/14, 405/14, 409/04, 409/14, 417/04, 417/14) and specific pharmaceutical compositions (A61K 31/426, 31/454, 31/4155). Therapeutic indications span cardiovascular (A61P 9/00), neurological (A61P 25/08, 25/28), anti-inflammatory (A61P 29/00), antimicrobial (A61P 31/00), anticancer (A61P 35/00), and general disease treatment applications (A61P 43/00). The patent designates all EPO member states.

This is a routine patent publication notice with no compliance obligations. Pharmaceutical companies and researchers developing autophagy modulators should review the patent claims to assess freedom-to-operate for their programs. Legal and R&D teams should evaluate potential licensing opportunities or design-around strategies for any compounds falling within the disclosed structural families.

Source document (simplified)

← EPO Patent Bulletin

AUTOPHAGY INDUCING COMPOUNDS AND USES THEREOF, IN PARTICULAR FOR A SYSTEMIC TREATMENT OF DISEASES AND CONDITIONS

Publication EP4433161A1 Kind: A1 Mar 25, 2026

Applicants

Samsara Therapeutics Inc., Institut National de la Santé et de la
Recherche Médicale (INSERM), Université de Paris Cité, Sorbonne Université, Assistance Publique - Hôpitaux de Paris

Inventors

HAMLEY, Peter, GALLOWAY, Warren, KEPP, Oliver, KROEMER, Guido

IPC Classifications

A61P 9/00 20060101AFI20230526BHEP A61P 25/08 20060101ALI20230526BHEP A61P 25/28 20060101ALI20230526BHEP A61P 29/00 20060101ALI20230526BHEP A61P 31/00 20060101ALI20230526BHEP A61P 35/00 20060101ALI20230526BHEP A61P 43/00 20060101ALI20230526BHEP C07D 401/14 20060101ALI20230526BHEP C07D 403/04 20060101ALI20230526BHEP C07D 403/14 20060101ALI20230526BHEP C07D 405/14 20060101ALI20230526BHEP C07D 409/04 20060101ALI20230526BHEP C07D 409/14 20060101ALI20230526BHEP C07D 417/04 20060101ALI20230526BHEP C07D 417/14 20060101ALI20230526BHEP A61K 31/426 20060101ALI20230526BHEP A61K 31/454 20060101ALI20230526BHEP A61K 31/4155 20060101ALI20230526BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

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