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USPTO Patent US12584907B1: Hydrogel for Organoid Patterning

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Published March 24th, 2026
Detected March 24th, 2026
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Summary

The USPTO has granted patent US12584907B1 for a viscoelastic hydrogel designed for organoid patterning and vascularization. The patent, assigned to The Florida State University Research Foundation, Inc., details a cell scaffold using methacrylated hyaluronic acid and dopamine-modified hyaluronic acid for culturing spinal cord models and blood-spinal cord barrier models.

What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12584907B1, titled "Hydrogel for organoid patterning and vascularization." This patent covers a novel cell scaffold composed of methacrylated hyaluronic acid (HAMA) and dopamine-modified hyaluronic acid (HA-Cat). The scaffold is designed to regulate organoid patterning and vascularization, specifically enabling the co-culture of spinal cord spheroids or organoids with blood vessel spheroids to create blood-spinal cord barrier models. The patent was granted on March 24, 2026, to The Florida State University Research Foundation, Inc.

This patent grant represents a new intellectual property development in the field of regenerative medicine and biomedical research. While not a regulatory rule imposing obligations, it signifies a technological advancement that may influence future research and development in areas such as spinal cord injury treatment, drug testing platforms, and the creation of in vitro disease models. Companies and research institutions operating in biotechnology, pharmaceuticals, and medical device development should be aware of this patent, as it may impact their freedom to operate or provide opportunities for licensing and collaboration.

Source document (simplified)

← USPTO Patent Grants

Viscoelastic hydrogel regulation of organoid patterning and vascularization

Grant US12584907B1 Kind: B1 Mar 24, 2026

Assignee

The Florida State University Research Foundation, Inc.

Inventors

Changchun Zeng, Yan Li, Xingchi Chen

Abstract

Disclosed herein are spinal cord models including a cell scaffold including methacrylated hyaluronic acid (HAMA) and dopamine-modified hyaluronic acid (HA-Cat), and a spinal cord spheroid or organoid or a fragment thereof cultured on the cell scaffold. Said spinal cord spheroids or organoids or fragments thereof can be co-cultured with blood vessel spheroid organoids to form blood-spinal cord barrier models. Also disclosed herein are methods of making and using said models.

CPC Classifications

G01N 33/5082 C12N 5/0618 C12N 5/0691 C12N 5/0697 C12N 2513/00 C12N 2533/40 C12N 2537/10

Filing Date

2025-04-10

Application No.

19175432

Claims

13

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Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12584907B1

Who this affects

Applies to
Drug manufacturers Medical device makers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3345 Medical Device Manufacturing
Activity scope
Biotechnology Research Drug Development
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Research & Development
Topics
Biotechnology Medical Devices

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