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Patent Application for 4-Amino-5-Methyl Pyridin-2-One Production Process

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Published September 22nd, 2025
Detected March 26th, 2026
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Summary

The USPTO has published a patent application (US20260085044A1) detailing an improved process for producing 4-amino-5-methyl-(1H)-pyridin-2-one and its derivatives. The application, filed by MinAscent Technologies GmbH, describes a method using ammonium salts under pressure without gaseous ammonia, aiming for high yield and purity while reducing container corrosion.

What changed

This document is a published patent application from the USPTO for a new process to produce 4-amino-5-methyl-(1H)-pyridin-2-one and its derivatives. The application, filed by MinAscent Technologies GmbH, claims an improved method involving the reaction of 4-hydroxy-5-methyl-(1H)-pyridin-2-one with an ammonium salt under pressure, specifically avoiding the use of aqueous or gaseous ammonia. This approach is intended to achieve high yields and purity while minimizing corrosion to reaction vessels.

As this is a patent application, it does not impose direct regulatory obligations on companies. However, it signifies potential future intellectual property developments in the chemical and pharmaceutical manufacturing sectors. Companies involved in the synthesis of pyridin-2-one derivatives should monitor this application and related patents for potential licensing opportunities or to understand the evolving landscape of production technologies.

Source document (simplified)

← USPTO Patent Applications

PROCESS FOR THE PRODUCTION OF 4-AMINO-5-METHYL-(1H)-PYRIDIN-2-ONE AND DERIVATIVES

Application US20260085044A1 Kind: A1 Mar 26, 2026

Assignee

MinAscent Technologies GmbH

Inventors

Martin KÜHNAST, Jean NONNENMACHER, Yvonne RICHTER

Abstract

An improved process for the production of 4-amino-5-methyl-(1H)-pyridin-2-one and derivatives. In the process, 4-hydroxy-5-methyl-(1H)-pyridin-2-one is reacted under pressure with an ammonium salt without adding aqueous ammonia or feeding in gaseous ammonia to provide the target compounds in high yield and high purity. The reaction mixture is not or much less corrosive to enamel coatings of a reaction container surface, since gaseous ammonia as reagent is not used.

CPC Classifications

C07D 213/73

Filing Date

2025-09-22

Application No.

19335373

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Named provisions

Abstract Assignee Inventors

Classification

Agency
USPTO
Published
September 22nd, 2025
Instrument
Notice
Legal weight
Non-binding
Stage
Draft
Change scope
Minor
Document ID
US20260085044A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Chemical Synthesis Drug Manufacturing
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Intellectual Property Chemical Manufacturing

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