MDMA Prodrug Carbamate Compounds - Apoapsis Holdings
Summary
USPTO granted Patent US12600708B2 to Apoapsis Holdings, LLC for novel MDMA prodrug carbamate compounds and synthesis methods. The patent covers 19 claims for compounds that are enzymatically cleaved in vivo to produce low-toxicity alcohols. The inventors include Denton W. Hoyer, Robert F. Roscow, Rong Ling, and Chuanjun Gao.
What changed
USPTO granted a new patent for MDMA prodrug carbamate compounds. The patent covers novel compounds that can be activated in vivo as prodrugs, with enzymatic cleavage producing alcohols of low toxicity that are well tolerated in humans.
Patent holders and licensees may benefit from the exclusivity granted by this patent. Researchers and pharmaceutical companies developing MDMA-based therapies should monitor this patent when planning drug development programs involving prodrug approaches.
What to do next
- Monitor patent portfolio for potential licensing opportunities
- Review patent claims for research and development implications
Archived snapshot
Apr 14, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Prodrug compounds of 3,4-methylenedioxymethamphetamine (MDMA) and methods of synthesizing the same
Grant US12600708B2 Kind: B2 Apr 14, 2026
Assignee
Apoapsis Holdings, LLC
Inventors
Denton W. Hoyer, Robert F. Roscow, Rong Ling, Chuanjun Gao
Abstract
The present invention includes a novel class of MDMA carbamates that can be activated in vivo as prodrugs. The MDMA prodrugs of the invention are enzymatically cleaved in vivo and produce alcohols of low toxicity that are well tolerated and metabolized in humans.
CPC Classifications
C07D 317/58 C07D 327/04
Filing Date
2023-07-26
Application No.
18226767
Claims
19
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