Large-Scale Liposomal Aminoglycoside Manufacturing Method

USPTO published Insmed's patent application for a large-scale manufacturing method of liposomal drug formulations containing aminoglycosides such as amikacin. The method utilizes a specific relative flow rate ratio of lipid to drug streams to produce liposomes with high encapsulation efficiency, resulting in formulations with an overall lipid-to-drug weight ratio of less than 1:1. The patent is classified under CPC codes A61K 9/1277 (liposomes) and A61K 31/7036 (amikacin derivatives).

For pharmaceutical manufacturers developing or producing liposomal aminoglycoside formulations, this patent establishes intellectual property protection for Insmed's manufacturing process. Competitors seeking to manufacture similar formulations at scale may need to design around these claims or seek licensing arrangements. The application was filed December 9, 2025, under application number 19413999.