Hydrazone derivative with aryl-substituted terminal amine group and use thereof
Summary
USPTO granted Patent No. US12590071B2 to Korea Institute of Science and Technology on March 31, 2026, covering hydrazone derivatives where the terminal amine group is substituted with aryl or heteroaryl groups. The patent includes 14 claims relating to compounds represented by Formulas 3 and 4, and methods of making these compounds. The patent relates to heterocyclic organic chemistry with potential pharmaceutical applications.
What changed
USPTO granted Patent No. US12590071B2 to Korea Institute of Science and Technology on March 31, 2026, for a hydrazone derivative where the terminal amine group is substituted with an aryl or heteroaryl group. The patent contains 14 claims covering compounds represented by Formula 3 and Formula 4, including unsubstituted and substituted benzothiazolyl, quinolinyl, indolyl, pyrrolopyridinyl, and oxodihydrobenzothiazolyl derivatives. The filing date was December 26, 2018, under Application No. 17415382.\n\nThis patent grant establishes enforceable intellectual property rights in the United States for the Korea Institute of Science and Technology. Third parties interested in developing, manufacturing, or commercializing products incorporating these hydrazone derivatives should conduct freedom-to-operate analyses to assess potential infringement risks. The patent does not impose compliance obligations but rather grants exclusive rights that others must respect.
Archived snapshot
Mar 31, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof
Grant US12590071B2 Kind: B2 Mar 31, 2026
Assignee
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors
Ae Nim Pae, Yun Kyung Kim, Sang Min Lim, Sungsu Lim, Jihye Seong, Jae Wook Lee, Ji Yeon Song, Seulgi Shin, Hyean Jeong Jeong, Woo Seung Son, Haeun Lee, Da Mi Lim, Seok Kyu Kim, Jee Yun Ahn, Chae Won Kim, Ashwini Machhindra Londhe, Lizaveta Gotina, Hyojin Kim, Hye Yeon Lee, Nam Gyung Kim, Eunji Cha, Kunhee Kim, Ji Woong Lim
Abstract
A compound represented by Formula 3 as described herein, or a pharmaceutically acceptable salt thereof, and a method of making a Formula 3 compound. In Formula 3: R1 is hydrogen; and
Cy is unsubstituted benzothiazol-6-yl, benzothiazol-5-yl, quinolin-3-yl, indolyl, pyrrolopyridinyl, oxodihydrobenzothiazolyl, or oxodihydrobenzoxazolyl; orsubstituted benzothiazol-6-yl, benzothiazol-5-yl, indazolyl, quinolin-3-yl, indolyl, pyrrolopyridinyl, oxodihydrobenzothiazolyl, oxodihydrobenzoxazolyl, or oxodihydrobenzoimidazolyl, each of which is substituted with: (i) methyl, ethyl, propyl, butyl, isopropyl, isobutyl, methoxy, ethoxy, fluoro, chloro, bromo, trifluoroethyl, difluoromethyl, trifluoromethoxy, dimethylcarbamoyl, phenoxy, isopropoxy, methylamino or dimethylamino; or (ii) phenyl, pyridinyl, furanyl, or thiophenyl unsubstituted or substituted with at least one of methyl, fluoro, and dimethylamino.
A compound of Formula 4 as described herein, or a pharmaceutically salt thereof.
CPC Classifications
C07D 241/42 C07D 209/14 C07D 215/38 C07D 231/12 C07D 231/56 C07D 237/14 C07D 239/26 C07D 239/30 C07D 239/34 C07D 277/28 C07D 277/82 C07D 417/04 C07D 417/12 C07D 471/04 C07D 487/04 C07C 255/66
Filing Date
2018-12-26
Application No.
17415382
Claims
14
Named provisions
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