Epoxytiglienone Compounds for Disrupting Gram-negative Bacterial Biofilms
Summary
The USPTO has published patent application US20260097011A1 for epoxytiglienone compounds designed to disrupt biofilms comprising Gram-negative bacteria. The application covers methods of dispersing established biofilms through localized administration, including topical or injection delivery, as well as methods for preventing biofilm formation on medical devices. Inventors include David William Thomas, Paul Warren Reddell, Glen Mathew Boyle, and others. The application was filed on December 2, 2025.
What changed
The USPTO published patent application US20260097011A1 disclosing epoxytiglienone compounds and their use in disrupting Gram-negative bacterial biofilms. The application claims methods of dispersing established biofilms through exposure to epoxytiglienone compounds or salts thereof, methods of treating infections via localized administration (topical or injection), and methods of preventing biofilm formation or dispersing biofilms on medical devices.
For pharmaceutical and medical device companies, this patent application represents potential prior art that could affect freedom-to-operate analyses for anti-biofilm technologies targeting Gram-negative bacteria. Healthcare providers treating biofilm-related infections may benefit from understanding this emerging therapeutic approach. The application's broad claim scope covering both treatment methods and medical device applications suggests a wide potential utility across multiple product categories.
What to do next
- Monitor patent prosecution status for potential licensing opportunities
- Review claims for freedom-to-operate analysis in anti-infective development
Archived snapshot
Apr 13, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
BIOFILM DISRUPTION
Application US20260097011A1 Kind: A1 Apr 09, 2026
Inventors
David William THOMAS, Paul Warren REDDELL, Glen Mathew BOYLE, Jason Kingsley CULLEN, Victoria Anne GORDON, Katja Etel HILL, Lydia Charlotte POWELL, Manon F. PRITCHARD, Peter G. PARSONS
Abstract
The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.
CPC Classifications
A61K 31/336 A61K 45/06 A61P 31/04
Filing Date
2025-12-02
Application No.
19406565
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