Substituted Entecavir Monophosphate Alaninamide Phenolic Esters for Hepatitis B
Summary
The USPTO granted Patent No. US12590097B2 to Beijing Junke Huayuan Med Tech Co., Ltd. on March 31, 2026, covering entecavir monophosphate alaninamide phenolic ester derivatives for hepatitis B treatment. The patent grants exclusive rights to the pharmaceutical compound for resisting hepatitis B virus. This is a routine patent grant notification.
What changed
The USPTO issued Patent No. US12590097B2 to Beijing Junke Huayuan Med Tech Co., Ltd. for a substituted entecavir monophosphate alaninamide phenolic ester compound effective against hepatitis B virus. The patent, filed April 1, 2021, covers 11 claims including the compound of formula II, its non-toxic salts, and methods of using the derivative for preparing antiviral drugs.
Pharmaceutical companies developing or manufacturing hepatitis B treatments should verify whether their products or compounds fall within the scope of this patent. Patent grants do not impose compliance deadlines but establish enforceable intellectual property rights that could affect freedom to operate in this therapeutic area.
Archived snapshot
Mar 31, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Substituted entecavir monophosphate alaninamide phenolic esters for resisting hepatitis b virus
Grant US12590097B2 Kind: B2 Mar 31, 2026
Assignee
BEIJING JUNKE HUAYUAN MED TECH CO., LTD.
Inventors
Bohua Zhong, Hongwu Li, Xiaozai Wang
Abstract
An entecavir monophosphate alaninamide phenolic ester derivative is represented by formula II. It has non-toxic pharmaceutically acceptable salts. In formula II, X is H, halogen, R or —OR, and R is a C1-3 alkyl or a substituted C1-3 alkyl. The entecavir monophosphate alaninamide phenolic ester derivative or the non-toxic pharmaceutically acceptable salt thereof can be used in the preparation of a drug for resisting the hepatitis B virus.
CPC Classifications
A61K 31/522 C07D 487/04
Filing Date
2021-04-01
Application No.
17907684
Claims
11
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