CRISPR/Cas9 Gene Editing Method for Beta-Amyloid Pathway Attenuation
Summary
USPTO published patent application US20260097136A1 filed by Wisconsin Alumni Research Foundation on November 12, 2025. The application covers CRISPR/Cas9 constructs designed for C-terminal truncation of human amyloid precursor protein (APP) to attenuate the beta-amyloid pathway implicated in Alzheimer's disease, along with methods of making and using such constructs.
The publication provides public notice of the claimed gene-editing technology and its potential therapeutic applications in neurodegenerative disease. No enforceable rights are granted until a patent issues following examination.
What changed
USPTO published patent application US20260097136A1, a new biotech patent application from Wisconsin Alumni Research Foundation covering CRISPR/Cas9 constructs for C-terminal truncation of human amyloid precursor protein (APP) and methods of making and using the constructs.
Affected parties including biotech researchers, pharmaceutical companies, and gene therapy developers should monitor this application as it progresses through examination. If the patent issues, it could cover CRISPR-based therapeutic approaches targeting APP for Alzheimer's disease treatment, potentially limiting freedom to operate in this space without a license.
What to do next
- Monitor for patent issuance and examiner actions
- Review claims for potential infringement implications
Archived snapshot
Apr 12, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
GENE EDITING-BASED METHOD OF ATTENUATING THE BETA-AMYLOID PATHWAY
Application US20260097136A1 Kind: A1 Apr 09, 2026
Assignee
Wisconsin Alumni Research Foundation
Inventors
Subhojit Roy, Jichao Sun
Abstract
Described herein are CRISPR/Cas9 constructs designed for the C-terminal truncation of human amyloid precursor protein (APP) as well as methods of making and using such a construct.
CPC Classifications
A61K 48/0066 A61K 9/0019 A61K 48/0008 A61K 48/0058 A61K 48/0075 A61P 25/28 C07K 14/4711 C12N 9/22 C12N 15/102 C12N 15/907 C12N 2310/20 C12N 2740/16043 C12N 2750/14143
Filing Date
2025-11-12
Application No.
19387161
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