Compstatin Analogues Patent for Complement Inhibitors

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Compstatin analogues and their medical uses

Grant US12600749B2 Kind: B2 Apr 14, 2026

Assignee

ZP SPV 3 K/S

Inventors

Anne Pernille Tofteng Shelton, Jacob Ulrik Fog, Jens Kvist Madsen

Abstract

Compstatin analogues having improved binding and complement-inhibiting activity as compared to the 13 amino acid compstatin peptide (ICVVQDWGHHRCT (cyclic C2-C12)) (SEQ ID NO: 1) are described, in particular compstatin analogues that additionally possess useful physicochemical properties, such as increased solubility. These analogues include variants with an isoleucine residue at position 3 in place of the wild type valine residue, which provides compstatin peptides with improved binding and complement-inhibiting activity and also enables the introduction of other modifications, for example modifications that are capable of increasing solubility, such as the introduction of charged or polar amino acids at position 9 and/or the introduction of N- and/or C-terminal sequences.

CPC Classifications

C07K 7/08 A61K 47/542 A61K 38/00

Filing Date

2024-03-11

Application No.

18601031

Claims

19

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