Lipid-Encapsulated Dual-Cleaving Endonuclease for DNA and Gene Editing

USPTO published application US20260098248A1 for a lipid-encapsulated dual-cleaving endonuclease enabling non-viral gene editing methods. The application claims methods to edit genes by administering a chimeric nuclease to cells or organisms without viral vectors, with CPC classifications including C12N 9/22, A61K 31/7088, A61K 38/465, C12N 15/11, C12N 15/907, C12N 2310/20, and C12N 2800/80. For pharmaceutical and biotechnology companies engaged in gene therapy development, this published application represents prior art that may affect freedom-to-operate analyses for non-viral gene editing technologies. The application has not yet been granted and is still pending USPTO examination.