ATSDR Substance Nominations for Toxicological Profiles

Regs.gov: Agency for Toxic Substances and Disease Registry

Detected March 17th, 2026

Summary

The Agency for Toxic Substances and Disease Registry (ATSDR) is seeking public nominations for substances to be evaluated for upcoming toxicological profiles. This notice opens a comment period for interested parties to suggest substances and provide rationale, with comments due by May 18, 2026.

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What changed

The Agency for Toxic Substances and Disease Registry (ATSDR) has issued a notice soliciting nominations for substances to be evaluated for toxicological profiles. This action is part of ATSDR's mandate under SARA to assess hazardous substances commonly found at Superfund sites. The agency is opening a public docket to receive nominations and comments on which substances should be prioritized for profile development, considering both substances on the official Substance Priority List (SPL) and others nominated by the public.

Regulated entities, particularly those in the pharmaceutical and chemical industries, as well as environmental and public health organizations, are invited to submit nominations and supporting data by May 18, 2026. While this is a nomination process and not a rule, providing input can influence future ATSDR research priorities. There are no direct compliance obligations or penalties associated with this notice, but participation may inform future regulatory considerations or research efforts by ATSDR.

What to do next

Submit nominations for substances to be evaluated for toxicological profiles by May 18, 2026.
Provide rationale and supporting data for any nominated substances not on the ATSDR Substance Priority List.

Source document (simplified)

Content

ACTION:

Notice with comment period.

SUMMARY:

The Agency for Toxic Substances and Disease Registry (ATSDR), within the Department of Health and Human Services (HHS), announces
that it is soliciting nominations of substances to be evaluated for an upcoming set of toxicological profiles. ATSDR is opening
a docket for the public to submit nominations and provide comments on which toxicological profiles are developed next. Members
of the public, government agencies, or private organizations may comment on which substances they are concerned about so that
ATSDR may take this information into consideration when developing future toxicological profiles.

DATES:

Written comments must be received on or before May 18, 2026.

ADDRESSES:

You may submit comments, identified by Docket No. ATSDR-2026-0001 by either of the methods listed below. Do not submit comments
by email. ATSDR does not accept comments by email.

• Federal eRulemaking Portal: http://www.regulations.gov. Follow the instructions for submitting comments.

• Mail: Agency for Toxic Substances and Disease Registry, Office of Innovation and Analytics, 4770 Buford Highway, Mail Stop S106-5,
Atlanta, GA, 30341-3717. Attn: Docket No. ATSDR-2026-0001.

Instructions: All submissions received must include the agency name and Docket Number. All relevant comments received will be posted without
change to http://www.regulations.gov, including any personal information provided. For access to the docket to read background documents or comments received, go
to http://www.regulations.gov.

FOR FURTHER INFORMATION CONTACT:

Farhana Rahman, Agency for Toxic Substances and Disease Registry, Office of Innovation and Analytics, 4770 Buford Highway,
Mail Stop S106-5, Atlanta, GA, 30341-3717; Email: ATSDRToxProfileFRNs@cdc.gov; Phone: 1-800-232-4636.

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq. ] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C.
9601 et seq. ] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) concerning hazardous substances
most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate
for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous
Substances, also known as the Substance Priority list (SPL). This list identifies 275 hazardous substances found at NPL sites
that ATSDR has determined currently pose the most significant potential threat to human health. For more information on ATSDR's
SPL, visit https://www.atsdr.cdc.gov/programs/substance-priority-list.html.

Substances To Be Evaluated for Toxicological Profile Development

Each year, ATSDR develops a list of substances to be considered for toxicological profile development. The nomination process
includes consideration of all substances on ATSDR's SPL, as well as other substances nominated by the public.

Submission of Nominations for Toxicological Profile Development

This notice invites public nominations of substances for toxicological profile development. If nominating a substance that
is not on the SPL, please include the rationale for the nomination and any supporting data. ATSDR will evaluate data and information
associated with nominated substances and will determine the final list of substances to be chosen for toxicological profile
development.

Public Participation

Interested persons or organizations are invited to participate by submitting nominations for substances. These submissions
may include written views and data to support the nomination. Please note that comments received, including attachments and
other supporting materials, are part of the public record and are subject to public disclosure. Comments will be posted on https://www.regulations.gov. Therefore, do not include any information in your comment or supporting materials that you consider confidential or inappropriate
for public disclosure. If

  you include your name, contact information, or other information that identifies you in the body of your comments, that information
  will be on public display. ATSDR will review all submissions and may choose to redact, or withhold, submissions containing
  private or proprietary information such as Social Security numbers, medical information, inappropriate language, or duplicate/near
  duplicate examples of a mass-mail campaign related to substances being nominated. Do not submit comments by email. ATSDR does
  not accept comments by email.

Donata Green, Associate Director, Office of Policy, Planning and Partnerships, Agency for Toxic Substances and Disease Registry. [FR Doc. 2026-05164 Filed 3-16-26; 8:45 am] BILLING CODE 4163-70-P