Methods for Controlling Treatment Volumes in Pulsed Electric Field Treatments
Summary
USPTO granted Patent US12599429B2 to North Carolina State University covering methods for electrotherapy via pulsed electric field. The patent describes modifying or killing target cells while simultaneously controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses through dynamically adjusted electrical pulse delivery profiles. The patent contains 20 claims.
What changed
USPTO granted Patent US12599429B2 to North Carolina State University for methods of electronically controlled electrotherapy using pulsed electric fields. The patent covers dynamically adjusting energy delivery profiles in response to measurements to achieve controlled cell modification or killing while simultaneously controlling secondary physical, biological, and systemic outcomes including treatment volumes, thermal gradients, muscle stimulation, and immune responses.
For assignees and potential licensees, this patent establishes exclusionary rights in electrotherapy technology. Parties developing competing electrotherapy systems should review claims for potential infringement risk. Universities and research institutions conducting similar pulsed electric field research should consider freedom-to-operate analysis.
What to do next
- Monitor patent maintenance deadlines
- Evaluate licensing opportunities
- Monitor for potential infringement
Archived snapshot
Apr 14, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Methods for controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses in pulsed electric field treatments
Grant US12599429B2 Kind: B2 Apr 14, 2026
Assignee
NORTH CAROLINA STATE UNIVERSITY
Inventors
Michael Benjamin Sano, Christopher Fesmire, Ross A. Petrella
Abstract
Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.
CPC Classifications
A61B 18/1477 A61B 2017/00194 A61B 2018/00005 A61B 2018/00023 A61B 2018/00577 A61B 2018/00613 A61B 2018/00642 A61B 2018/00648 A61B 2018/00672 A61B 2018/00678 A61B 2018/00702 A61B 2018/0072 A61B 2018/00726 A61B 2018/00744 A61B 2018/00761 A61B 2018/00767 A61B 2018/00791 A61B 2018/00839 A61B 2018/00875 A61B 2018/00892 A61B 2034/104 A61B 2090/374 A61B 2090/3762 A61B 2090/378 A61N 1/0502 A61N 1/06 A61N 1/1327 A61N 1/36002
Filing Date
2020-11-23
Application No.
17779306
Claims
20
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