Hyperspectral Image-Guided Ocular Imager for Alzheimer's Disease Pathologies

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Hyperspectral image-guided ocular imager for Alzheimer's Disease pathologies

Grant US12599331B2 Kind: B2 Apr 14, 2026

Assignee

RETISPEC INC.

Inventors

Eliav Shaked, Grzegorz Dmochowski

Abstract

A non-invasive device for detecting Alzheimer's Disease-associated pathologies, comprising a fundus camera comprising a spectral reflectance imaging unit that includes a broadband light source and a light sensor and a lens assembly to focus light from the broadband light source onto a fundus of an eye, and one or more processors to detect reflected and/or backscattered light from the eye, illuminated by the broadband light source, using the light sensor for determining spectral reflectance information, generate a plurality of spectral reflectance maps comprising counts of reflected and/or backscattered light at a different wavelength or a different range of wavelengths, assign a weight to each of the spectral reflectance maps, and determine one or more regions of interest from the weighted spectral reflectance maps as being a potential Alzheimer's Disease-associated pathology based on a detection of one or more biomarkers indicative of Tauopathy.

CPC Classifications

A61B 5/4088 A61B 3/0025 A61B 3/1225 A61B 3/14 A61B 5/0075 A61B 5/7264 A61B 2576/02 A61B 5/7267 A61B 3/12 G01N 1/286 G01N 1/30 G01N 21/55 G01N 21/65 G01N 33/6896 G01N 2001/2873 G01N 2333/4709 G01N 2800/2821 G16H 30/40 G16H 50/70

Filing Date

2023-12-13

Application No.

18538524

Claims

27

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