DEA: Xylazine Involved in 6,096 Overdose Deaths in 2023
Summary
The DEA issued a public safety alert stating that xylazine was involved in 6,096 overdose deaths in 2023, making it the fourth most common drug in such fatalities. The alert indicates that all 50 states have reported the presence of xylazine in the illicit drug supply.
What changed
The Drug Enforcement Administration (DEA) has issued a public safety alert highlighting the increasing prevalence of xylazine in the illicit drug supply. According to CDC data cited by the DEA, xylazine was implicated in 6,096 overdose deaths in 2023, positioning it as the fourth most common drug involved in these fatalities. The alert further notes that xylazine has now been reported in all 50 states, underscoring its widespread distribution.
This notice serves as a critical alert to public health officials, healthcare providers, and law enforcement regarding the significant and growing threat posed by xylazine. While this is an informational notice and not a regulatory rule, it signals a heightened focus on this substance. Regulated entities, particularly those in healthcare and drug distribution, should be aware of these statistics and the potential for increased scrutiny or future regulatory actions concerning xylazine. No specific compliance actions are mandated by this notice, but awareness of the trend is crucial for risk assessment and operational planning.
What to do next
- Review internal protocols for identifying and handling suspected xylazine-involved overdoses.
- Stay informed about DEA and CDC updates regarding xylazine and its impact on public health.
- Assess potential risks and operational impacts related to the increasing prevalence of xylazine in the illicit drug supply.
Archived snapshot
Mar 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
DEA HQ @DEAHQ #Xylazine continues to spread in the illicit drug supply. @CDCgov reports it became the 4th most common drug involved in overdose deaths in 2023, with 6,096 deaths reported. NFLIS data show all 50 states have reported xylazine. dea.gov/xylazine-infor @TheJusticeDept
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8:19 pm · 17 Mar 2026
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