USPTO Patent Grant for Caged-Degron Molecular Feedback Circuits
Summary
The USPTO has granted patent US12583896B2 to The Regents of the University of California for caged-degron-based molecular feedback circuits. The patent covers methods of modulating signaling pathways in cells using these circuits, with a filing date of January 6, 2020.
What changed
The United States Patent and Trademark Office (USPTO) has granted patent US12583896B2 for "Caged-degron-based molecular feedback circuits and methods of using the same." The patent, assigned to The Regents of the University of California, details molecular feedback circuits that utilize caged-degrons to control signaling pathways. It includes claims related to nucleic acids encoding these circuits, cells containing them, and methods for modulating cellular signaling pathways through genetic modification.
This patent grant is primarily relevant for entities involved in biotechnology research and development, particularly in the pharmaceutical and medical device sectors. While it does not impose direct compliance obligations, it signifies new intellectual property in the field of synthetic biology and cellular engineering. Companies operating in this space should be aware of this patent to ensure their research and development activities do not infringe upon the granted claims.
Archived snapshot
Mar 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Caged-degron-based molecular feedback circuits and methods of using the same
Grant US12583896B2 Kind: B2 Mar 24, 2026
Assignee
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors
David Baker, Scott Boyken, Hana El-Samad, Marc Lajoie, Robert Langan, Andrew Ng
Abstract
Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit.
CPC Classifications
C07K 14/4705 C07K 2319/02 C07K 14/7051 C07K 14/435 A61K 35/17 A61K 48/00 C12N 2740/16043 C12N 15/63 C12N 15/86 C12N 15/79 C12N 15/85 G01N 33/5047
Filing Date
2020-01-06
Application No.
17419236
Claims
11
Named provisions
Related changes
Get daily alerts for USPTO Patent Grants - Peptides (C07K)
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from USPTO.
The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when USPTO Patent Grants - Peptides (C07K) publishes new changes.
Subscribed!
Optional. Filters your digest to exactly the updates that matter to you.