USPTO Patent Applications - Biotech (C12N)

Method for Efficient Biosynthesis of Rebaudioside M2 Using Glycosyltransferase

The USPTO has published a patent application detailing a method for the efficient biosynthesis of rebaudioside M2 using glycosyltransferase. The assignee, GUILIN LAYN NATURAL INGREDIENTS CORP., claims this method provides an environmentally friendly way to produce rebaudioside M2 with no by-products, potentially reducing production costs.

Patent Application for Engineered Pyrococcus Enzymes

The USPTO has published patent application US20260085299A1 for engineered Pyrococcus enzymes designed for improved nucleotide analogue incorporation in DNA sequencing. The application was filed on May 27, 2025.

Patent Application: Genome Modification Compositions and Methods

The USPTO has published a new patent application (US20260085301A1) from Confluence Genetics, LLC, detailing compositions and methods for targeting and eliminating cells with pre-determined DNA sequences using Cas12a2 protein. The application was filed on September 19, 2025.

Patent Application: Plant Pest Control using Cas12a2 Protein

The USPTO has published a patent application (US20260085302A1) from Confluence Genetics, LLC, detailing methods and compositions for controlling plant pests using Cas12a2 protein and guide polynucleotides. The application describes targeting specific DNA or RNA sequences within plant pests for elimination.

Novel cell wall hydrolases target Cutibacterium acnes conditions

The USPTO has published a patent application (US20260085303A1) detailing novel cell wall hydrolases designed to target Cutibacterium acnes. The application describes compositions and uses for treating conditions associated with this bacterium.

Methods for adding polymers to ribonucleic acids

The USPTO has published a patent application detailing methods for adding polymers of non-canonical nucleotides to the 3' end of ribonucleic acids (RNA). The application, filed by inventors from institutions including the University of California, describes techniques that may be used for RNA analysis and identification. This publication represents a new patent application and does not impose immediate regulatory obligations.

Patent Application for Nucleic Acid Library Preparation

The USPTO has published a new patent application, US20260085306A1, detailing ligation-free methods for preparing nucleic acid libraries for high-throughput sequencing. The application was filed on January 16, 2024, and published on March 26, 2026.

Genome-wide insulator screening system disclosed

The USPTO has published a patent application detailing a genome-wide insulator screening system. The system, comprising specific MAI-seq vectors, is designed for high-sensitivity screening of genomic insulators and is applicable to any species.

Methods for Generating cDNA Library from RNA

The USPTO has published a patent application (US20260085308A1) detailing methods for the fast and efficient generation of cDNA libraries from RNA. The application, filed on September 11, 2023, by inventors Keith Brown, Steven Head, and Phillip Ordoukhanian, describes a method adaptable for automation.

USPTO Patent Application: VOCs for Cellular Communication

The USPTO has published patent application US20260079169A1, detailing a method for evaluating cancer behavior using volatile organic compounds (VOCs) detected in a mutual headspace between cancer cells and control samples. The application, filed on November 24, 2025, by inventors from institutions including Technion-Israel Institute of Technology, outlines a novel diagnostic approach.

USPTO Patent Application for Magnetic Separation of Biological Populations

The USPTO has published a new patent application (US20260079086A1) detailing an apparatus, system, and method for high-yield magnetic separation of biological populations. The application describes a system involving a cell engineering cassette, a fluidic pathway with entrapment features, and a translatable magnet array for separating subpopulations.

USPTO Patent Application: 3D Immunomechanical Organoid Model

The USPTO has published a patent application (US20260079151A1) for a 3D immunomechanical organoid model developed by the University of Notre Dame. This model is designed for observing myeloid cell interactions and for applications in drug screening and microgravity experiments.

USPTO Patent Application: Neuron Generation from Pluripotent Stem Cells

The USPTO has published a patent application (US20260079153A1) detailing methods for generating mature neurons from pluripotent stem cells. The disclosed methods involve overexpressing specific splicing factors to facilitate the study of neurodegenerative diseases and the accelerated derivation of mature neurons.