Thrombus Aspiration PPCI Trial for Acute STEMI
ClinicalTrials.gov Studies
Summary
This is a prospective, multicenter, randomized, controlled, single-blind clinical trial (NCT07551700) investigating whether adding standardized manual thrombus aspiration to primary percutaneous coronary intervention (PPCI) improves heart health outcomes in adults with acute ST-segment elevation myocardial infarction (STEMI) and high thrombus burden. The study will compare PPCI plus manual thrombus aspiration versus PPCI alone across two participant groups, with follow-up assessments at 30 days, 6 months, and 1 year. Participants will undergo coronary angiography, randomization, echocardiograms, and optional cardiac MRI to measure heart tissue damage and function.
“The goal of this clinical trial is to learn if adding standardized manual thrombus aspiration to primary percutaneous coronary intervention (PPCI) works better to improve heart health outcomes and protect long-term heart function in adults with acute ST-segment elevation myocardial infarction (STEMI) and a high blood clot burden in the heart's arteries.”
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What changed
The document is a ClinicalTrials.gov registry entry describing a planned clinical trial. Clinical trial registrations are informational database records and do not create compliance obligations or impose regulatory requirements on regulated entities.
Affected parties including healthcare providers conducting cardiac research, clinical investigators, and patients considering trial participation should note that this registry entry documents a planned study evaluating a cardiac procedure approach. Registry entries themselves do not impose new compliance obligations but reflect adherence to standard clinical trial registration requirements.
Archived snapshot
Apr 27, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Efficacy of Thrombus Aspiration in Patients With Acute ST-Segment Elevation Myocardial Infarction: A Prospective, Multicenter, Randomized, Controlled, Single-Blind Clinical Trial
N/A NCT07551700 Kind: NA Apr 27, 2026
Abstract
The goal of this clinical trial is to learn if adding standardized manual thrombus aspiration to primary percutaneous coronary intervention (PPCI) works better to improve heart health outcomes and protect long-term heart function in adults with acute ST-segment elevation myocardial infarction (STEMI) and a high blood clot burden in the heart's arteries. The main questions it aims to answer are:
- Does PPCI plus manual thrombus aspiration lower the risk of serious heart problems one year after treatment, compared to PPCI alone?
- Can manual thrombus aspiration better protect long-term heart function in people with a high blood clot burden? Researchers will compare two groups of participants-one group getting PPCI plus manual thrombus aspiration and one group getting only PPCI-to see if the aspiration treatment leads to fewer serious heart problems, better long-term heart function, and similar safety (including no higher risk of stroke).
Participants will:
- Have a heart artery scan (coronary angiography) to confirm a high blood clot burden
- Be randomly assigned to one of the two treatment groups for their PPCI procedure
- Complete follow-up checks at 30 days, 6 months, and 1 year after treatment, including heart function tests (like echocardiograms)
- Have heart magnetic resonance (CMR) scans if selected, to measure heart tissue damage and heart function
- Have their heart health status and any adverse events recorded throughout the study
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: Manual Thrombus Aspiration, Primary Percutaneous Coronary Intervention (PPCI)
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