SWE Measures Renal Stiffness for Hydronephrosis in Pregnancy
Summary
This prospective observational clinical trial (NCT07547891) will evaluate shear wave elastography (SWE) as a diagnostic tool to differentiate obstructive from physiological hydronephrosis in pregnant women, addressing a clinical challenge where conventional ultrasound cannot reliably distinguish between the two conditions. The study aims to establish optimal SWE cut-off values using receiver operating characteristic (ROC) analysis to guide clinical management of hydronephrosis in pregnancy. Participants will undergo clinical assessment, laboratory investigations, and ultrasound evaluation including SWE measurements to assess renal cortical stiffness as a non-invasive quantitative marker.
“This prospective observational study aims to evaluate the diagnostic accuracy of renal cortical stiffness measured by shear wave elastography (SWE) in differentiating obstructive from physiological hydronephrosis in pregnant women.”
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What changed
This clinical trial registration documents a prospective observational study evaluating shear wave elastography (SWE) as a diagnostic modality for assessing hydronephrosis in pregnant women. The study will recruit pregnant participants presenting with hydronephrosis and measure renal cortical stiffness using SWE, comparing results against clinical assessment and laboratory investigations to determine whether SWE can reliably distinguish physiological hydronephrosis (common and benign during pregnancy) from obstructive hydronephrosis requiring intervention.
For healthcare providers and diagnostic imaging specialists, this study represents a potential advance in non-invasive prenatal diagnosis. If SWE demonstrates adequate diagnostic performance with determined cut-off values, it could become a standard tool for evaluating hydronephrosis in pregnant patients, reducing reliance on more invasive or ionizing-radiation-based procedures. Clinical investigators in maternal-fetal medicine and radiology departments may wish to monitor trial outcomes for incorporation into future diagnostic protocols.
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Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Renal Cortical Stiffness Measured by Shear Wave Elastography for Evaluation of Hydronephrosis in Pregnancy
Observational NCT07547891 Kind: OBSERVATIONAL Apr 23, 2026
Abstract
Hydronephrosis is common during pregnancy and is often physiological; however, it may also result from true obstruction requiring intervention. Differentiating between physiological and obstructive hydronephrosis remains a clinical challenge using conventional ultrasound.
This prospective observational study aims to evaluate the diagnostic accuracy of renal cortical stiffness measured by shear wave elastography (SWE) in differentiating obstructive from physiological hydronephrosis in pregnant women. Participants presenting with hydronephrosis will undergo clinical assessment, laboratory investigations, and ultrasound evaluation including SWE measurements.
The diagnostic performance of SWE will be assessed using receiver operating characteristic (ROC) analysis, and optimal cut-off values will be determined. The study aims to provide a safe, non-invasive, and quantitative tool to improve diagnosis and guide management in pregnant patients with hydronephrosis.
Conditions: Hydronephrosis in Pregnancy
Interventions: Shear Wave Elastography (SWE)
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