Study Compares Caries Removal Methods, Oral Microbiome Effects
ClinicalTrials.gov Studies
Summary
The National Institutes of Health registered a clinical study on ClinicalTrials.gov (NCT07538089) evaluating how selective and non-selective caries removal methods affect oral microbiome composition using 16S rRNA gene sequencing. The study targets dental caries patients and will assess microbial diversity outcomes from two intervention approaches.
What changed
The NIH registered a new clinical trial (NCT07538089) on ClinicalTrials.gov investigating how different caries removal techniques affect the oral microbiome. The study will compare selective and non-selective caries removal methods and evaluate microbial diversity changes through 16S rRNA gene sequencing.
For dental healthcare providers and clinical investigators, this registry entry represents emerging research into biologically compatible treatment approaches. While the study does not create compliance obligations, its findings may inform future evidence-based treatment guidelines for caries management.
Archived snapshot
Apr 20, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Caries Removal Methods and Microbiome Changes
N/A NCT07538089 Kind: NA Apr 20, 2026
Abstract
Dental caries management approaches may influence not only tissue removal but also the microbial composition within the cavity. However, clinical evidence on how different caries removal methods affect the oral microbiome remains limited.
This study aims to evaluate the effects of selective and non-selective caries removal methods on the diversity and composition of the oral microbiome using 16S rRNA gene sequencing. The findings are expected to help identify biologically compatible treatment approaches that effectively reduce pathogenic microorganisms.
Conditions: Caries, Dental
Interventions: Non-selective caries removal, Selective caries removal
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