Sodium Bicarbonate Contrast EIT Lung Perfusion Pilot Study
Summary
NIH registered a prospective observational pilot study (NCT07542366) evaluating whether sodium bicarbonate can serve as a safe and effective contrast agent for electrical impedance tomography (EIT) imaging of lung blood flow in mechanically ventilated adults. The study will compare sodium bicarbonate (5%) against hypertonic saline (10% sodium chloride) within the same participants to assess image quality and short-term safety including effects on blood pressure, heart rhythm, and blood tests. Participants include adults with acute respiratory failure, ARDS, pneumonia, or critical illness in ICU settings.
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What changed
NIH registered a new observational pilot study (NCT07542366) titled 'The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study.' The study aims to determine whether sodium bicarbonate (5%) can be used safely and effectively as a contrast agent for EIT imaging of pulmonary perfusion in mechanically ventilated adults, comparing it against hypertonic saline (10% sodium chloride) within the same participants.
This is a study registration notice with no compliance implications. Clinical investigators and healthcare institutions conducting ICU-based imaging research may find this relevant for understanding current feasibility研究方向. The study does not impose regulatory requirements or create reporting obligations for regulated entities.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study
Observational NCT07542366 Kind: OBSERVATIONAL Apr 21, 2026
Abstract
The goal of this observational pilot study is to learn if sodium bicarbonate can be used safely and effectively as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on mechanical ventilation. Electrical impedance tomography (EIT) is a bedside imaging method that uses a soft belt with small sensors around the chest to track changes in electrical signals related to breathing and blood flow.
The main questions are:
Does sodium bicarbonate create clear, readable lung blood flow images with EIT? Are these images similar in quality and pattern to images made with hypertonic saline (10% sodium chloride)? Is the short-term safety profile acceptable, including effects on blood pressure, heart rhythm, and blood tests?
Researchers will compare two contrast agents within the same participant to see if image quality and lung blood flow patterns match:
Hypertonic saline (10% sodium chloride) Sodium bicarbonate (5%)
Participants will:
Have an EIT belt placed around the chest during routine ICU care Pause the ventilator briefly during image capture to reduce motion Receive two small intravenous boluses through an existing central line, one of hypertonic saline and one of sodium bicarbonate, with time between doses Have routine monitoring of vital signs; blood gases and electrolytes may be checked per clinical care Be observed for any short-term side effects Findings from this study will show whether sodium bicarbonate is a practical and sa...
Conditions: Acute Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Pneumonia, Critical Illness, Feasibility of Contrast-enhanced Electrical Impedance Tomography (EIT) for Pulmonary Perfusion Assessment in Mechanically Ventilated Adults
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