Shanghai Wennai Therapeutics US12612383B2 Pyrrolidine Derivative Nav1.8 Inhibitor
Summary
The USPTO granted Patent US12612383B2 to SHANGHAI WENNAI THERAPEUTICS CO., LTD. on April 28, 2026, covering polysubstituted pyrrolidine derivative compounds, their stereoisomers, tautomers, deutero-derivatives, and pharmaceutically acceptable salts. The patented compounds function as sodium channel subtype Nav1.8 inhibitors and are intended for pharmaceutical use in the treatment and prevention of pain-related disorders. The patent contains 8 claims and lists Shanghai Yu as the sole inventor.
About this source
Granted patents in USPTO classification C07D, covering heterocyclic organic compounds: the chemical core of most small-molecule drugs. Around 160 grants a month. Unlike applications, grants are enforceable. This feed is the best public-domain signal of which small-molecule compositions have just become defensible IP, which matters for generic entry timing, freedom-to-operate opinions, and competitive intelligence. Watch this if you practice pharma IP law, manage a drug discovery patent portfolio, advise on compound licensing, or scout ANDA opportunities as brand drugs approach loss of exclusivity. Recent grants cover apalutamide process improvements and bioactive phenolate ionic complexes.
What changed
The USPTO issued Patent US12612383B2 to Shanghai Wennai Therapeutics Co., Ltd., granting exclusive rights to polysubstituted pyrrolidine derivative compounds and their pharmaceutical compositions for use as Nav1.8 sodium channel inhibitors. The patent covers therapeutic applications in pain-related disorders, including both treatment and prevention indications. Stereoisomers, tautomers, deutero-derivatives, and pharmaceutically acceptable salts of the claimed compounds fall within scope.
For pharmaceutical companies developing pain-management therapies, this patent establishes intellectual property barriers around Nav1.8 inhibitor compounds in the pyrrolidine chemical space. Competitors pursuing Nav1.8 targets for analgesics should conduct freedom-to-operate analyses and consider structural modifications to avoid infringement. The 8 granted claims suggest a focused but defensible patent portfolio around specific structural configurations.
Archived snapshot
Apr 28, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Polysubstituted pyrrolidine derivative, preparation method therefor and use thereof
Grant US12612383B2 Kind: B2 Apr 28, 2026
Assignee
SHANGHAI WENNAI THERAPEUTICS CO., LTD.
Inventors
Shanghai Yu
Abstract
The present invention discloses a kind of polysubstituted pyrrolidine derivative compounds represented by the formula (I), stereoisomers, tautomers, deutero-derivatives or pharmaceutically acceptable salts thereof, as well as preparation methods and uses of the compounds and pharmaceutical compositions comprising the compounds, stereoisomers, tautomers, deutero-derivatives or pharmaceutically acceptable salts thereof, wherein the compounds can be used as sodium channel subtype Nav1.8 inhibitors, and their pharmaceutical use in the treatment and prevention of pain-related disorders.
CPC Classifications
C07D 401/12 C07D 207/16 C07D 401/14 C07D 403/12 C07D 207/02 C07D 207/04 C07D 295/04 C07D 295/195 C07D 405/12 C07D 405/14 C07D 413/14 C07B 59/002 A61K 31/4155 A61K 31/4439 A61K 31/496 A61K 31/395 A61K 31/40 A61P 25/04 A61P 29/00
Filing Date
2025-04-25
Application No.
19190493
Claims
8
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