Randomized Trial Comparing 5 vs 8 cmH₂O PEEP in Prone Lumbar Surgery
ClinicalTrials.gov Studies
Summary
Clinical trial NCT07545733 registered on ClinicalTrials.gov is a randomized controlled trial comparing the effects of 5 cmH₂O versus 8 cmH₂O positive end-expiratory pressure (PEEP) levels on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). The study will evaluate driving pressure and mechanical power as key determinants of ventilator-induced lung stress. Conditions include lumbar disc herniation, spinal surgery, prone position, and general anesthesia. No regulatory obligations or compliance requirements are imposed by this clinical trial registration.
“This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA).”
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What changed
Clinical trial NCT07545733 has been registered on ClinicalTrials.gov as a randomized controlled trial evaluating two PEEP levels (5 and 8 cmH₂O) during prone lumbar surgery under total intravenous anesthesia. The study aims to assess the impact of different PEEP levels on respiratory parameters, driving pressure, and mechanical power as determinants of ventilator-induced lung stress. This is an informational research registration and does not impose any compliance obligations on healthcare providers, manufacturers, or other regulated entities.
For healthcare institutions and clinical researchers, this trial registration represents a data point in the medical literature regarding optimal ventilatory strategies for patients in prone position. The findings, once published, may inform clinical practice guidelines for perioperative respiratory management in spinal surgery. No immediate action is required by regulatory or compliance teams.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery
N/A NCT07545733 Kind: NA Apr 22, 2026
Abstract
This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.
Conditions: Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia
Interventions: Mechanical Ventilation (PEEP)
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