Fused Bicyclic RAF Inhibitors and Methods for Use Thereof
Summary
The USPTO published patent application US20260092063A1 for fused bicyclic RAF inhibitors as potential cancer therapeutics, including colorectal cancer treatment. Inventors include Andrew Belfield, Clifford David Jones, Jean-François Margathe, and Chiara Colletto. The application was filed on 2025-05-12 under Application No. 19205876.
What changed
The USPTO published a patent application for novel fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or their salts, tautomers, or stereoisomers, claiming methods for treating cancer including colorectal cancer. The application (US20260092063A1, filed May 12, 2025) includes CPC classifications C07D 471/04, A61K 45/06, and C07D 405/14.
Patent application publications are informational disclosures requiring no compliance action from regulated entities. While no immediate deadlines or penalties apply, pharmaceutical companies and cancer researchers may wish to review the claims for potential freedom-to-operate concerns or licensing opportunities related to RAF kinase inhibition in oncology applications.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF
Application US20260092063A1 Kind: A1 Apr 02, 2026
Inventors
Andrew BELFIELD, Clifford David JONES, Jean-François MARGATHE, Chiara COLLETTO
Abstract
The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.
CPC Classifications
C07D 471/04 A61K 45/06 C07D 405/14
Filing Date
2025-05-12
Application No.
19205876
Named provisions
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Source
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