Pyrimidine Derivatives Inhibit c-Kit Kinase for Cancer Treatment
Summary
Merck Patent GmbH has filed US Patent Application US20260109697A1, published April 23, 2026, covering 4-(imidazo[1,2-a]pyridin-3-yl)-pyrimidine derivatives as inhibitors of c-Kit kinase for cancer treatment. The application, filed October 30, 2025 (Application No. 19373991), names inventors Dieter Dorsch, Andreas Blum, and Hans-Peter Buchstaller. CPC classifications span C07D 471/04, A61K 31/506, and related pharmaceutical compound categories.
“Compounds of the formula I are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.”
About this source
USPTO classification C07D covers heterocyclic organic compounds: the chemical core of most small-molecule drugs, including kinase inhibitors, GLP-1 receptor agonists, antibiotics, antivirals, and CNS therapies. Every newly published application in C07D lands in this feed, around 160 a month. Applications publish 18 months after filing, so this feed reveals what medicinal chemistry groups at Pfizer, Novartis, Roche, Shionogi, and others were synthesizing in the prior year and a half. Watch this if you run a medicinal chemistry program, file patent clearance for new drug candidates, scout competitor pipelines before clinical readouts, or track heterocyclic innovation across therapeutic areas.
What changed
Merck Patent GmbH has published US Patent Application US20260109697A1, a published patent application for 4-(imidazo[1,2-a]pyridin-3-yl)-pyrimidine derivatives as c-Kit kinase inhibitors for cancer treatment. The application was filed October 30, 2025, and published April 23, 2026, listing inventors Dieter Dorsch, Andreas Blum, and Hans-Peter Buchstaller. The compounds of formula I are claimed as inhibitors of c-Kit kinase for the treatment of cancer, with R1, R2, R3, V, X, Y, and Z substituents defined across multiple substitution patterns.
For parties monitoring competitive IP landscapes in oncology therapeutics, this published application establishes a priority date of October 30, 2025. Competitors developing c-Kit inhibitor programs should assess potential freedom-to-operate implications. This document is a published patent application, not a granted patent — it represents a pending claim under examination rather than an issued enforceable right.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES
Application US20260109697A1 Kind: A1 Apr 23, 2026
Assignee
Merck Patent GmbH
Inventors
Dieter Dorsch, Andreas Blum, Hans-Peter Buchstaller
Abstract
Compounds of the formula I are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer. R1 denotes H, Hal, CF3, NO2, A, [C(R3)2]nN(R3)2, [C(R3)2]nHet1, OR3, O[C(R3)2]nN(R3)2, O[C(R3)2]nS(O)mR3, O[C(R3)2]COOR3, O[C(R3)2]˜COON(R3)2, O[C(R3)2]nHet1, O[C(R3)2]nN(R3)Het1, O[C(R3)2]nPh, or O[C(R3)2]nCyc. R2 denotes H or CH3. R3 denotes H or A. V denotes H or Hal. X denotes O or N(R3). Y denotes phenylene, pyridin-diyl, thiophen-diyl, 1,3-thiazol-diyl or pyrazol-diyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal and/or A. Z denotes CON(R3)2, phenyl, Het4 or —O-A.
CPC Classifications
C07D 471/04 A61K 31/506 A61K 31/5377 A61K 31/541 A61K 45/06 C07D 239/42 C07D 403/12 C07D 519/00
Filing Date
2025-10-30
Application No.
19373991
Parties
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