Predicting Cell Differentiation Using HICA Content
Summary
The USPTO has published application US20260109921A1, filed November 8, 2022 by inventors Shiori NAKAZAWA, Midori KATO, Hikaru SAITO, Hiroko HANZAWA, and Shizu TAKEDA. The invention discloses a non-invasive method for predicting the differentiation level of cultured cells by measuring HICA content in culture supernatant collected after differentiation induction begins but before it ends, then inputting the measurement into a prediction model. The method may be implemented using a prediction device and aims to enable early-stage differentiation assessment without destructive testing.
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 263 changes logged to date.
What changed
The USPTO published patent application US20260109921A1 covering a method and device for predicting cell differentiation levels using HICA (alpha-hydroxyisocaproic acid) content measurements in culture supernatant. The method involves three steps: collecting culture supernatant after differentiation induction starts but before it ends, measuring HICA content in that supernatant, and inputting the HICA measurement into a prediction model to generate a differentiation level prediction. CPC classifications indicate applications in cell culture apparatus (C12M) and cell/tissue culture technologies (C12N).
Parties interested in cell culture-based bioprocessing, regenerative medicine research, or related biotechnology development should note this publication for prior art purposes. The application establishes an early priority date of November 8, 2022 and may affect freedom-to-operate analyses for similar non-invasive cell monitoring approaches.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
PREDICTION METHOD AND PREDICTION DEVICE
Application US20260109921A1 Kind: A1 Apr 23, 2026
Inventors
Shiori NAKAZAWA, Midori KATO, Hikaru SAITO, Hiroko HANZAWA, Shizu TAKEDA
Abstract
Prediction of a differentiation level of a cultured cell is performed non-invasively and simply in an early stage from the end of differentiation induction. A prediction method includes collecting the culture supernatant of the prediction target cultured cell after the start of differentiation induction and before the end of differentiation induction, measuring the content of HICA in the culture supernatant of the collected prediction target cultured cell (step S22), and inputting the content of HICA in the culture supernatant of the prediction target cultured cell measured in the prediction model to predict a differentiation level of the prediction target cultured cell (step S23).
CPC Classifications
C12M 1/343 C12M 3/00 C12N 5/0696 C12N 2506/45
Filing Date
2022-11-08
Application No.
19118254
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