Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
Summary
A non-randomized comparative clinical study registered on ClinicalTrials.gov under NCT07547202 will evaluate the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in 44 adult patients with Stage II and III periodontitis. Participants are divided into two equal groups of 22 current smokers and 22 non-smokers; all will undergo scaling and root planing followed by a six-week post-therapy follow-up visit. The study is registered via changeflow.com/changebridge and appears in the ClinicalTrials.gov studies feed.
“This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis.”
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What changed
This ClinicalTrials.gov registry entry documents a prospective non-randomized comparative clinical study (NCT07547202) evaluating the effect of non-surgical periodontal therapy on salivary biomarkers and clinical periodontal parameters in patients with periodontitis. The study enrolled 44 adult patients split into two groups of 22 smokers and 22 non-smokers, all undergoing standardized scaling and root planing. Primary outcomes include changes in Dkk-1, Sclerostin, PLAP-1, and clinical parameters measured at baseline and six weeks post-therapy. Clinical investigators conducting or planning periodontal research studies involving salivary biomarkers should note this trial's design, inclusion criteria, and outcome measures as relevant to protocol development or peer research alignment. No compliance obligations or regulatory actions are imposed; this is a registration record for informational purposes.
The trial registration provides no enforcement implications. Healthcare providers, clinical investigators, and research institutions conducting similar periodontal or biomarker research may find the study parameters relevant for protocol design or competitive landscape awareness but bear no regulatory reporting obligation from this entry. This document is non-binding and does not create new legal obligations.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
N/A NCT07547202 Kind: NA Apr 23, 2026
Abstract
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies.
- The trial is a non-randomized comparative clinical study.
- It includes 44 adult patients diagnosed with Stage II and III periodontitis.
- The participants are divided into two equal groups: 22 current smokers and 22 non-smokers.
- Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing.
- A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection.
- The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.
Conditions: Periodontitis, Smoking ( Cigarette)
Interventions: Non-surgical periodontal therapy (Scaling and root planing)
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