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USPTO Patent Grant US12582652B2 for Ion Channel Modulator

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Summary

The USPTO has granted patent US12582652B2 to Praxis Precision Medicines, Inc. for a novel ion channel modulator compound. The patent covers methods of treating neurological disorders and conditions associated with neuronal excitability.

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What changed

The United States Patent and Trademark Office (USPTO) has granted patent US12582652B2 to Praxis Precision Medicines, Inc. The patent, titled "3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator," claims a specific compound and its use in treating neurological disorders, including those linked to mutations in central nervous system sodium channel genes like SCN1A, SCN2A, and SCN8A.

This patent grant signifies the protection of intellectual property for a new therapeutic compound. While not imposing direct compliance obligations on other entities, it establishes exclusivity for Praxis Precision Medicines in the use and development of this specific molecule. Companies operating in the pharmaceutical and drug development sectors, particularly those researching ion channel modulators or neurological treatments, should be aware of this granted patent to avoid potential infringement and to inform their own R&D strategies.

Archived snapshot

Mar 24, 2026

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← USPTO Patent Grants

3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator

Grant US12582652B2 Kind: B2 Mar 24, 2026

Assignee

Praxis Precision Medicines, Inc.

Inventors

Michael Kristopher Mathieu Kahlig, Marion Wittmann, Zoe A. Hughes, Bernard Ravina

Abstract

The present disclosure is generally directed to methods of treating a disease, disorder, or condition, e.g., a neurological disorder, a disorder associated with excessive neuronal excitability, or a disorder associated with de novo gain-of-function or loss-of-function mutations in major central nervous system sodium channel genes, such as for example, SCN1A, SCN2A, and SCN8A, using a Compound 1, or a pharmaceutically acceptable salt thereof, of the following formula:

CPC Classifications

A61K 31/4985 C07D 487/04

Filing Date

2024-10-25

Application No.

18927377

Claims

28

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Last updated

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12582652B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Intellectual Property Protection
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Intellectual Property Drug Development

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