USPTO Patent Grant US12582652B2 for Ion Channel Modulator
Summary
The USPTO has granted patent US12582652B2 to Praxis Precision Medicines, Inc. for a novel ion channel modulator compound. The patent covers methods of treating neurological disorders and conditions associated with neuronal excitability.
What changed
The United States Patent and Trademark Office (USPTO) has granted patent US12582652B2 to Praxis Precision Medicines, Inc. The patent, titled "3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator," claims a specific compound and its use in treating neurological disorders, including those linked to mutations in central nervous system sodium channel genes like SCN1A, SCN2A, and SCN8A.
This patent grant signifies the protection of intellectual property for a new therapeutic compound. While not imposing direct compliance obligations on other entities, it establishes exclusivity for Praxis Precision Medicines in the use and development of this specific molecule. Companies operating in the pharmaceutical and drug development sectors, particularly those researching ion channel modulators or neurological treatments, should be aware of this granted patent to avoid potential infringement and to inform their own R&D strategies.
Archived snapshot
Mar 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator
Grant US12582652B2 Kind: B2 Mar 24, 2026
Assignee
Praxis Precision Medicines, Inc.
Inventors
Michael Kristopher Mathieu Kahlig, Marion Wittmann, Zoe A. Hughes, Bernard Ravina
Abstract
The present disclosure is generally directed to methods of treating a disease, disorder, or condition, e.g., a neurological disorder, a disorder associated with excessive neuronal excitability, or a disorder associated with de novo gain-of-function or loss-of-function mutations in major central nervous system sodium channel genes, such as for example, SCN1A, SCN2A, and SCN8A, using a Compound 1, or a pharmaceutically acceptable salt thereof, of the following formula:
CPC Classifications
A61K 31/4985 C07D 487/04
Filing Date
2024-10-25
Application No.
18927377
Claims
28
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Source
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