Non-Human Animals Expressing pH-Sensitive Immunoglobulin Sequences
Summary
The USPTO published patent application US20260107928A1, filed December 16, 2025, covering genetically modified non-human animals that express pH-sensitive immunoglobulin variable domains. The application names John McWhirter, Lynn Macdonald, Joel H. Martin, and Andrew J. Murphy as inventors, with Application No. 19421956. The invention relates to immunoglobulin genes comprising histidines in CDR regions, N-terminal regions, and loop 4 regions, enabling pH-sensitive antigen binding.
“Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a histidine codon, or the insertion of a histidine codon in a germline immunoglobulin nucleic acid sequence.”
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 268 changes logged to date.
What changed
The USPTO published a patent application for genetically modified non-human animals engineered to express pH-sensitive immunoglobulin variable domains containing histidine substitutions in CDR regions, N-terminal regions, and loop 4 regions. The application covers animals with modified heavy chain variable loci (V, D, J segments), modified light chain variable loci (V, J segments), and rearranged germline light chain genes.
Biotechnology and pharmaceutical companies engaged in antibody engineering or protein therapeutic research should monitor this application for potential implications on pH-sensitive immunoglobulin technologies.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Non-Human Animals Expressing pH-Sensitive Immunoglobulin Sequences
Application US20260107928A1 Kind: A1 Apr 23, 2026
Inventors
John McWhirter, Lynn Macdonald, Joel H. Martin, Andrew J. Murphy
Abstract
Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a histidine codon, or the insertion of a histidine codon in a germline immunoglobulin nucleic acid sequence. Immunoglobulin genes comprising histidines in one or more CDRs, in an N-terminal region, and/or in a loop 4 region are also provided. Immunoglobulin variable domains comprising one or more histidines (e.g., histidine clusters) substituted for non-antigen-binding non-histidine residues. Non-human animals that are progeny of animals comprising modified heavy chain variable loci (V, D, J segments), modified light chain variable loci (V, J segments), and rearranged germline light chain genes (VJ sequences) are also provided. Non-human animals that make immunoglobulin domains that bind antigens in a pH-sensitive manner are provided.
CPC Classifications
A01K 67/0275 A01K 67/0278 C07K 16/00 C12N 15/8509 A01K 2217/072 A01K 2217/075 A01K 2217/15 A01K 2227/105 A01K 2267/01 C07K 2317/10 C07K 2317/21 C07K 2317/92 C07K 2317/94 C12N 2800/204
Filing Date
2025-12-16
Application No.
19421956
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